- Pk:50 µG
- Protein/peptide type:Recombinant
- Source:E. coli
- Species:Human
- Environmentally Preferable:
- Tag sequence:His Tag
- Storage conditions:Stable for at least 1 year after receipt when stored at −20 °C. Working aliquots are stable for up to 3 months when stored at −20 °C.
- Protein synonyms:Bone Morphogenetic Protein 2|BMP2
- Protein/peptide name:BMP2
- Purity:>95% (SDS-PAGE)
- Sequence:289-396
- Formulation:Lyophilized from 0.2um-filtered solution in PBS.
Bone morphogenetic protein 2 (BMP-2) is a member of the BMP subgroup of the TGF-beta superfamily. It plays a dominant role in embryonic dorsalventral patterning, organogenesis, limb bud formation and bone formation and regeneration. BMP-2 signals through heterodimeric complexes composed of a type I receptor (Activin RI, BMP-RIA or BMP-RIB) and a type II receptor (BMP-RII or Activin RIIB). BMP-2 induces chondrocyte proliferation, endochondral bone formation, longitudinal bone growth and bone and cartilage repair. It induces ectopic bone formation or calcification by promoting osteogenic and chondrogenic differentiation in mesenchymal cells, stem cells and vascular smooth muscle cells. It also promotes the maintenance and repair of colonic epithelium, suppresses neuronal dopamine synthesis and release, induces apoptosis in medulloblastoma cells and is required for cardiac contractility.
Fusion-Tag: His Tag
This recombinant proteins is for research use only.