- Antigen name:Lymphocyte-specific Protein tyrosine kinase
- Antigen symbol:LCK
- Clonality:Monoclonal
- Conjugation:Unconjugated
- ELISA:Yes
- Host:Mouse
- Isotype:IgG2a
- Reactivity:Human
- Western blot:Yes
- Environmentally Preferable:
- Antigen synonyms:p56lck|LSK|tyrosine-protein kinase Lck|YT16|leukocyte C-terminal Src kinase|T-lymphocyte specific protein tyrosine kinase p56lck|p56(LSTRA) protein-tyrosine kinase|RP4-675E8.4|t cell-specific protein-tyrosine kinase|lymphocyte cell-specific protein-tyrosine kinase|proto-oncogene tyrosine-protein kinase LCK|pp58lck
- Immunogen:Ni-NTA purified truncated recombinant Lck expressed in E. Coli strain BL21 (DE3).
- Size:100 µl
- Pk:100 µl
Lck(lymphocyte-specific protein tyrosine kinase), with 509-amino acid protein (about 56 kDa), belongs to the Src non-receptor tyrosine kinases family. By virtue of common structural motifs, the Src family is composed of nine members in vertebrates, including Src, Yes, Fgr, Frk, Fyn, Lyn, Hck, Lck and Blk. Lck is expressed predominantly in T cells and is localized to the inner surface of the plasma membrane. Lck is activated after T cell stimulation and is required for T-cell proliferation and IL-2 production. Aberrant expression or activation of Lck kinase has been reported in both lymphoid and nonlymphoid malignancies. In addition, inhibition of Lck has been a target to prevent lymphocyte activation and acute rejection.
Ascitic fluid containing 0.03% sodium azide.
Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
Type:
Antigen: LCK
Clonality: Monoclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG2a
Reactivity: Human