Specifications
- Antibody type:Primary
- Antigen name:Runt-related Transcription Factor 2
- Antigen symbol:RUNX2
- Clonality:Polyclonal
- Conjugation:Cy5.5®
- Host:Rabbit
- ImmunoChemistry:Yes
- Isotype:IgG
- Reactivity:Human
- Environmentally Preferable:
- Cross adsorption:No
- Form:liquid
- Gene ID:860
- Antigen synonyms:Acute myeloid leukemia 3 protein|PEBP2A|CBFA1|PEBP2-alpha A|SL3/AKV core-binding factor alpha A subunit|Polyomavirus enhancer-binding protein 2 alpha A subunit|OSF2|OSF-2|Core-binding factor subunit alpha-1|RUNX2|Runt-related transcription factor 2|PEA2-alpha A|CBF-alpha-1|Osteoblast-specific transcription factor 2|SL3-3 enhancer factor 1 alpha A subunit|AML3|Oncogene AML-3
- Modification:phospho-Ser451
- Storage buffer:Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
- Storage temperature:Store at 4°C for 12 months
- Concentration:1 μg/μl
- Shipping temperature:4°C
- Purification:Purified by Protein A
- Pk:100 µl
Specifications
About this item
Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation.
Recommended Dilutions: IF(IHC-P): 1:50-200
Type: Primary
Antigen: RUNX2
Clonality: Polyclonal
Clone:
Conjugation: Cy5.5®
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human