- Antibody type:Primary
- Antigen name:Mannan-binding Lectin Serine Peptidase 1
- Antigen symbol:MASP1
- Clonality:Polyclonal
- Conjugation:Alexa Fluor® 647
- Host:Rabbit
- ImmunoChemistry:Yes
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Environmentally Preferable:
- Cross adsorption:No
- Form:liquid
- Gene ID:5648
- Antigen synonyms:Complement Factor MASP-3|MASP1|CRARF|Mannan-binding lectin serine protease 1|Serine protease 5|CRARF1|RaRF|Ra-reactive factor serine protease p100|PRSS5|MASP-1|Mannose-binding lectin-associated serine protease 1|Mannan-binding lectin serine protease 1 heavy chain
- Storage buffer:Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
- Storage temperature:Store at 4°C for 12 months
- Concentration:1 μg/μl
- Shipping temperature:4°C
- Immunogen:130-180/488
- Purification:Purified by Protein A
- Pk:100 µl
Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5.
Recommended Dilutions: IF(IHC-P): 1:50-200
Type: Primary
Antigen: MASP1
Clonality: Polyclonal
Clone:
Conjugation: Alexa Fluor® 647
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat