Specifications
- Antibody type:Primary
- Antigen name:DNA (cytosine-5-)-methyltransferase 3 beta
- Antigen symbol:DNMT3B
- Clonality:Polyclonal
- Conjugation:Cy5.5®
- Host:Rabbit
- ImmunoChemistry:Yes
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Environmentally Preferable:
- Cross adsorption:No
- Form:liquid
- Gene ID:1789
- Antigen synonyms:ICF|DNA MTase HsaIIIB|DNA (cytosine-5)-methyltransferase 3B|ICF1|RP5-1085F17.2|DNA methyltransferase HsaIIIB|M.HsaIIIB
- Storage buffer:Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
- Storage temperature:Store at 4°C for 12 months
- Concentration:1 μg/μl
- Shipping temperature:4°C
- Immunogen:1-50/812
- Purification:Purified by Protein A
- Pk:100 µl
Specifications
About this item
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity). In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Function as transcriptional corepressor by associating with ZHX1.
Recommended Dilutions: IF(IHC-P): 1:50-200
Type: Primary
Antigen: DNMT3B
Clonality: Polyclonal
Clone:
Conjugation: Cy5.5®
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat