Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GISTs), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GISTs, including all c-kit negative GISTs. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GISTs is nearly identical: 94.4% vs. 94.7%.
Type: Primary
Antigen: TMEM16A
Clonality: Monoclonal
Clone: DOG1.1
Conjugation: Biotin
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Human
- Catalog No:
- BNCB0725-500
- BNCB0725-100
- Antigen symbol:
- TMEM16A
- TMEM16A
- Antigen name:
- DOG-1
- DOG-1
- Antigen synonyms:
- ORAOV2|Anoctamin 1|TMEM16A|Discovered On Gastrointestinal Stromal Tumors Protein-1 (DOG-1),TAOS2|Calcium Activated Chloride Channel
- ORAOV2|Anoctamin 1|TMEM16A|Discovered On Gastrointestinal Stromal Tumors Protein-1 (DOG-1),TAOS2|Calcium Activated Chloride Channel
- Antibody type:
- Primary
- Primary
- Clonality:
- Monoclonal
- Monoclonal
- Conjugation:
- Biotin
- Biotin
- Clone:
- Clone DOG1.1
- Clone DOG1.1
- Reactivity:
- Human
- Human
- Host:
- Mouse
- Mouse
- Gene ID:
- 503074
- 503074
- Isotype:
- IgG1 kappa
- IgG1 kappa
- ImmunoChemistry:
- Yes
- Yes
- ImmunoFluorescence:
- Yes
- Yes
- Concentration:
- 0,1 mg/ml
- 0,1 mg/ml
- Storage buffer:
- PBS/0,1% BSA/0,05% azide
- PBS/0,1% BSA/0,05% azide
: VWR Collection
: VWR Collection
: VWR Chemicals
: VWR Chemicals
: VWR Collection
: VWR Collection
: KIMBERLY CLARK
: VWR Collection