Anti-Aconitase 1 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

BOSSBS-9848R-A680

Anti-Aconitase 1 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

BOSSBS-9848R-A680

Antibody type:
Primary
Antigen name:
Aconitase 1
Clonality:
Polyclonal
Conjugation:
Alexa Fluor® 680
Host:
Rabbit
ImmunoChemistry:
Yes
ImmunoFluorescence:
Yes
Isotype:
IgG
Reactivity:
Human,
Rat,
Mouse
Western blot:
Yes
Environmentally Preferable:
Epitope:
101-200/889
Form:
Liquid
Gene ID:
48
Antigen synonyms:
Ferritin repressor protein|Aconitate hydratase|Citrate hydro-lyase|IRP1|Iron responsive element binding protein 1|Cytoplasmic aconitate hydratase|IRE-BP 1|Aconitase|Iron-responsive element-binding protein 1|IREBP1|IRE BP 1|ACOC_HUMAN|ACO 1|ACONS|Aconitase1|Iron regulatory protein 1|IREB 1|ACO1|IRP 1|Citrate hydro lyase|IREB1|Aconitase 1 soluble|IREBP
Modification:
Unmodified
Storage buffer:
Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
Storage temperature:
Store at −20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Concentration:
1 µg/µl
Shipping temperature:
4 °C
Immunogen:
KLH conjugated synthetic peptide derived from human Aconitase 1/IRP-1
Purification:
Purified by Protein A
Pack type:
Vial
Pk:
100 µl

Iron metabolism is essential for sustaining mammalian homeostasis. Iron uptake and distribution is a highly regulated process in mammalian cells that is monitored by two iron sensing proteins; iron regulatory protein-1 and -2 (IRP-1 and -2), also known as iron responsive element-binding protein-1 and -2 (IREBP-1 and -2) or aconitase 1 and 2. IRP-1 and IRP-2 are important soluble regulatory factors that mediate iron uptake and storage in mammalian cells. They are capable of either repressing translation or enhancing mRNA stability by associating with stem-loop motifs known as iron-responsive elements (IREs). IRPs respond to stress mediators, iron concentration and Signalling factors, including nitrogen monoxide, cytokines and hydrogen peroxide.

Type: Primary
Antigen: Aconitase 1
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 680
Public Immunogen Range: 101-200/889
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat