Anti-ALKBH1 Rabbit Polyclonal Antibody (Cy3®)

BOSSBS-12565R-CY3

Anti-ALKBH1 Rabbit Polyclonal Antibody (Cy3®)

BOSSBS-12565R-CY3

Antibody type:
Primary
Antigen name:
AlkB Homolog 1, Histone H2A Dioxygenase
Antigen symbol:
ALKBH1
Clonality:
Polyclonal
Conjugation:
Cy3®
Host:
Rabbit
ImmunoChemistry:
Yes
Isotype:
IgG
Reactivity:
Human,
Rat,
Mouse
Environmentally Preferable:
Cross adsorption:
No
Form:
liquid
Gene ID:
8846
Antigen synonyms:
ABH|hABH|alkB|ABH1|ALKBH
Storage buffer:
Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Storage temperature:
Store at 4°C for 12 months
Concentration:
1 μg/μl
Shipping temperature:
4°C
Purification:
Purified by Protein A
Pk:
100 µl

ALKB protects DNA and RNA against damage from methylating compounds from the environment by directly reversing 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) cytotoxic alkylation lesions in DNA and RNA. The enzymes act by oxidative demethylation, utilizing ferrous iron and alpha-ketoglutarate as cofactors, 2-oxoglutarate as a co-substrate, and molecular oxygen as the oxidizing agent. Deficiencies in DNA and RNA repair in mammals are associated with cancer, neurological disease and developmental defects. ALKB plays a role in resistance to anti-cancer drugs which attempt to damage tumor DNA. Escherichia coli ALKB protein belongs to the superfamily of 2-oxoglutarate- and iron(II)-dependent oxygenases.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: ALKBH1
Clonality: Polyclonal
Clone:
Conjugation: Cy3®
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat