Anti-UNC5C Rabbit Polyclonal Antibody (Alexa Fluor® 647)

BOSSBS-11493R-A647

Anti-UNC5C Rabbit Polyclonal Antibody (Alexa Fluor® 647)

BOSSBS-11493R-A647

Antibody type:
Primary
Antigen name:
Unc-5 Netrin Receptor C
Antigen symbol:
UNC5C
Clonality:
Polyclonal
Conjugation:
Alexa Fluor® 647
Flow cytometry:
Yes
Host:
Rabbit
ImmunoChemistry:
Yes
Isotype:
IgG
Reactivity:
Human,
Rat,
Mouse
Environmentally Preferable:
Cross adsorption:
No
Form:
liquid
Antigen synonyms:
UNC5C_HUMAN.|Unc 5 homolog 3|Unc5 C.elegans homolog c|Netrin receptor UNC5C|UNC5H3|Unc 5 homolog C|Protein unc 5 homolog C|Unc5
Storage buffer:
Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Storage temperature:
Store at 4°C for 12 months
Concentration:
1 μg/μl
Shipping temperature:
4°C
Purification:
Purified by Protein A
Pk:
100 µl

The UNC5H family of proteins act as transmembrane receptors for netrin-1 and play a crucial role in axon guidance and migration of neural cells. Additionally, UNC5H receptors induce apoptosis when cleaved by a caspase, producing an intracellular fragment containing a death domain. This activity is blocked by the binding of netrin-1. In the absence of netrin-1, UNC5H receptors act as tumor suppressors by inhibiting anchorage-independent growth and invasion, but mutation of these receptors provides a potential mechanism for tumorigenicity. The expression of UNC5H receptors is down-regulated in multiple cancers, including colorectal, breast, ovary, uterus, stomach, lung, and kidney cancers. UNC5H3, also known as UNC5C, plays an important role in the development of spinal accessory motor neurons. It is also involved in mediating the repulsive action for netrin-1 and it serves as a stop signal for migratory cells.

Recommended Dilutions: Flow Cytometry: 1:20-100; IF(IHC-P): 1:50-200

Type: Primary
Antigen: UNC5C
Clonality: Polyclonal
Clone:
Conjugation: Alexa Fluor® 647
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat