670 Results for: "bmp"
Human Recombinant BMP2 (from E. coli)
Supplier: Prosci
Bone morphogenetic protein 2 (BMP-2) is a member of the BMP subgroup of the TGF-beta superfamily. It plays a dominant role in embryonic dorsalventral patterning, organogenesis, limb bud formation and bone formation and regeneration. BMP-2 signals through heterodimeric complexes composed of a type I receptor (Activin RI, BMP-RIA or BMP-RIB) and a type II receptor (BMP-RII or Activin RIIB). BMP-2 induces chondrocyte proliferation, endochondral bone formation, longitudinal bone growth and bone and cartilage repair. It induces ectopic bone formation or calcification by promoting osteogenic and chondrogenic differentiation in mesenchymal cells, stem cells and vascular smooth muscle cells. It also promotes the maintenance and repair of colonic epithelium, suppresses neuronal dopamine synthesis and release, induces apoptosis in medulloblastoma cells and is required for cardiac contractility.
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Anti-BMP-2 Rabbit Polyclonal Antibody (Biotin)
Supplier: Peprotech
Produced from sera of rabbits immunized with highly pure Recombinant Human/Murine/Rat BMP-2. AntiHuman/Murine/Rat BMP-2specific antibody was purified by affinity chromatography and then biotinylated.
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Human Recombinant BMP2 (from E. coli)
Supplier: Prosci
Bone morphogenetic protein 2 (BMP-2) is a member of the BMP subgroup of the TGF-beta superfamily. It plays a dominant role in embryonic dorsalventral patterning, organogenesis, limb bud formation and bone formation and regeneration. BMP-2 signals through heterodimeric complexes composed of a type I receptor (Activin RI, BMP-RIA or BMP-RIB) and a type II receptor (BMP-RII or Activin RIIB). BMP-2 induces chondrocyte proliferation, endochondral bone formation, longitudinal bone growth and bone and cartilage repair. It induces ectopic bone formation or calcification by promoting osteogenic and chondrogenic differentiation in mesenchymal cells, stem cells and vascular smooth muscle cells. It also promotes the maintenance and repair of colonic epithelium, suppresses neuronal dopamine synthesis and release, induces apoptosis in medulloblastoma cells and is required for cardiac contractility.
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Anti-BMP-2 Rabbit Polyclonal Antibody
Supplier: Peprotech
Produced from sera of rabbits immunized with highly pure Recombinant Human/Murine/Rat BMP-2. AntiHuman/Murine/Rat BMP-2specific antibody was purified by affinity chromatography employing an immobilized Human/Murine/Rat BMP-2 matrix.
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Rat Bone Morphogenetic Protein 4 (BMP-4) ELISA Kit
Supplier: AFG BIOSCIENCE LLC
Rat Bone Morphogenetic Protein 4 (BMP-4) ELISA Kit
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Mouse Bone MorphoGenetic Protein 2 (BMP-2) ELISA Kit, AFG Bioscience
Supplier: AFG BIOSCIENCE LLC
Mouse Bone MorphoGenetic Protein 2 (BMP-2) ELISA Kit, AFG Bioscience
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Human Bone Morphogenetic Protein 4(BMP-4) ELISA Kit 修改数据
Supplier: AFG BIOSCIENCE LLC
Human Bone Morphogenetic Protein 4(BMP-4) ELISA Kit 修改数据
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Human Recombinant BMP2 (from E. coli)
Supplier: Prosci
Bone Morphogenetic Protein-2 (BMP-2) is one of the bone-growth regulatory factors that belong to the transforming growth factor-beta (TGF-beta) superfamily of proteins. BMPs are synthesized as large precursor molecules, which are cleaved by proteolytic enzymes. The active form of BMP-2 can consist of a dimer of two identical proteins or a heterodimer of two related bone morphogenetic proteins.
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Anti-BMP-7 Rabbit Polyclonal Antibody (Biotin)
Supplier: Peprotech
Produced from sera of rabbits immunized with highly pure Recombinant Human BMP-7. AntiHuman BMP-7specific antibody was purified by affinity chromatography and then biotinylated.
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Human BMP-2 PicoKine ELISA Kit, Boster
Supplier: Boster Biological Technology
Sandwich ELISA kit of Quantitative Detection for Human BMP-2
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Human Recombinant BMP3 (from E. coli)
Supplier: Prosci
TGF-β family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis. As implied by their name, BMPs initiate, promote, and regulate the development, growth and remodeling of bone and cartilage. In addition to this role, BMPs are also involved in prenatal development and postnatal growth, remodeling and maintenance of a variety of other tissues and organs. BMP-3 is abundantly found in adult bone, and to a lesser extent fetal cartilage. BMP-3 inhibits osteogenesis and bone formation by activating a signaling cascade that antagonizes the signaling of pro-osteogenic BMPs. Recombinant human BMP-3 is a disulfide linked homodimeric protein that corresponds to residues 361 to 472 of the 472 amino acid BMP-3 precursor protein.
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Human Bone Morphogenetic Protein 6 (BMP-6) ELISA Kit, AFG Bioscience
Supplier: AFG BIOSCIENCE LLC
Human Bone Morphogenetic Protein 6 (BMP-6) ELISA Kit, AFG Bioscience
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Human Recombinant BMP-13 (from E. coli)
Supplier: Peprotech
Animal-Free Human BMP-13/CDMP-2 Recombinant Protein, Purity: >95%, Source: E.coli, Biological Activity: By its ability to induce alkaline phosphatase production by ATDC-5 cells, Synonyms: Bone Mor
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Mouse BMP-binding Endothelial Regulator Protein(BMPER) ELISA Kit
Supplier: AFG BIOSCIENCE LLC
Mouse BMP-binding Endothelial Regulator Protein(BMPER) ELISA Kit
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Anti-BMPER Rabbit Polyclonal Antibody
Supplier: Prosci
BMPER contains 1 TIL (trypsin inhibitory-like) domain, 5 VWFC domains and 1 VWFD domain.BMPER is the inhibitor of bone morphogenetic protein (BMP) functions. It may regulate BMP responsiveness of osteoblasts and chondrocytes.
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Human/Murine/Rat BMP-2 Standard ABTS ELISA Development Kit, PeproTech, Inc.
Supplier: Peprotech
PeproTech's Human/Murine/Rat BMP-2 ELISA development kit contains the key components required for the quantitative measurement of natural and/or recombinant human/murine/rat BMP-2 in a sandwich ELISA format.
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Human BMP and Activin Membrane-bound Inhibitor Homolog (BAMBI) ELISA Kit
Supplier: AFG BIOSCIENCE LLC
Human BMP and Activin Membrane-bound Inhibitor Homolog (BAMBI) ELISA Kit
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Rat BMP-7 ELISA Kit, Rockland Immunochemicals
Supplier: Rockland Immunochemical
Rat BMP-7 AccuSignal ELISA Kit
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Human Recombinant BMP6 (from HEK293 cells)
Supplier: Prosci
TGF-β family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis. As implied by their name, BMPs initiate, promote, and regulate the development, growth and remodeling of bone and cartilage. In addition to this role, BMPs are also involved in prenatal development and postnatal growth, remodeling and maintenance of a variety of other tissues and organs. Increasing evidence indicates that BMP-Smad signaling has a tumor suppressing activity and that BMPs can inhibit tumor growth. BMP-6 is abnormally expressed in breast cancer cell lines; however, its function in promoting breast cancer development is unknown. Recombinant human BMP-6 is a 26.2 kDa homodimeric glycoprotein consisting of two 117 amino acid subunits, which correspond to amino acid residues 397 to 513 of the full-length BMP-6 precursor.
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Human Recombinant BMP-10 (from HEK293 cells)
Supplier: Peprotech
Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-β superfamily of structurally related signaling proteins. Members of this superfamily are widely distributed throughout the body and are involved in diverse physiological processes during both pre- and postnatal life. BMP-10 plays a crucial role in the development of the embryonic heart by acting to stimulate and maintain cardiomyocyte proliferation. It can signal through various receptor complexes usually containing BMPR-1A, BMPR-1B, ALK1, ALK3, or ALK6. The interaction of BMP-10 with its specific receptors can induce signaling initiated by the phosphorylation of SMAD transcription factors, including SMAD1, SMAD5, or SMAD8, but can also induce SMAD independent processes. BMP-10 is structurally related to BMP-9, and both can inhibit endothelial cell proliferation and migration. Recombinant Human BMP-10 is a 24.4 kDa homodimeric disulfide-linked protein consisting of two 108 amino acid subunits, which correspond to amino acid residues 317 to 424 of the full-length BMP-10 precursor.
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Human BMP-4 PicoKine ELISA Kit, Boster
Supplier: Boster Biological Technology
Sandwich ELISA kit of Quantitative Detection for Human BMP-4
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Human;Mouse;Rat Recombinant BMP-2 (from E. coli)
Supplier: Peprotech
BMPs (Bone Morphogenetic Proteins) belong to the TGF-β superfamily of structurally related signaling proteins. BMP-2 is a potent osteoinductive cytokine, capable of inducing bone and cartilage formation in association with osteoconductive carriers such as collagen and synthetic hydroxyapatite. In addition to its osteogenic activity, BMP-2 plays an important role in cardiac morphogenesis, and is expressed in a variety of tissues, including lung, spleen, brain, liver, prostate ovary and small intestine. The functional form of BMP-2 is a 26 kDa protein composed of two identical 114 amino acid polypeptide chains linked by a single disulfide bond. Each BMP-2 monomer is expressed as the C-terminal part of a precursor polypeptide, which also contains a 23 amino acid signal sequence for secretion, and a 259 amino acid propeptide. After dimerization of this precursor, the covalent bonds between the propeptide (which is also a disulfide-linked homodimer) and the mature BMP-2 ligand are cleaved by a furin-type protease. Recombinant Human/Murine/Rat BMP-2 is a 26.0 kDa homodimeric protein consisting of two 115 amino acid polypeptide chains.
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Human Recombinant BMP-5 (from CHO cells)
Supplier: Peprotech
TGF-β family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis. As implied by their name, BMPs initiate, promote, and regulate the development, growth, and remodeling of bone and cartilage. In addition to this role, BMPs are also involved in prenatal development and postnatal growth, remodeling, and maintenance of a variety of other tissues and organs. BMP-5 is expressed in the nervous system, lungs and liver. It is a known regulator for dendritic growth in sympathetic neurons. BMP-5 is a 454 amino acid precursor protein that is cleaved to release the biologically active C-terminal mature protein. Recombinant Human BMP-5 is a 31.2 kDa homodimeric disulfide-linked protein consisting of two identical 138 amino acid chains.
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Mouse Recombinant BMP Receptor IA
Supplier: Prosci
ALK-3 is a type I receptor for bone morphogenetic proteins (BMPs) which belong to the protein kinase superfamily, TKL Ser/Thr protein kinase family and TGFB receptor subfamily. The BMP receptors consists of the type I receptors BMPR1A and BMPR1B and the type I I receptor BMPR2. Seven known type I serine/threonine kinases and five mammalian type II serine/threonine kinase receptors function in TGF-beta superfamily signal transduction. The downstream molecules of the type I BMP receptors include the Smad (Smad1, 5 and 8) proteins that are phosphorylated in a ligand-dependent manner, and relay the BMP signal from the receptors to target genes in the nucleus. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. ALK-3 contains a GS domain and a protein kinase domain. ALK-3 is widely expressed. Defects in BMPR1A gene are a cause of a significant proportion of cases of Juvenile polyposis syndrome (JPS).
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Anti-BMP7 Mouse Monoclonal Antibody [clone: M123-11A]
Supplier: Prosci
BMPs (bone morphogenetic proteins) belong to the TGF beta superfamily of structurally related signaling proteins. Members of this superfamily are widely represented throughout the animal kingdom and have been implicated in a variety of developmental processes. Proteins of the TGF beta superfamily are disulfide-linked dimers composed of two 12-15 kDa polypeptide chains. As implied by their name, BMPs initiate, promote and regulate bone development, growth, remodeling and repair.
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Anti-SMAD1 Rabbit Polyclonal Antibody
Supplier: Prosci
SMAD1 belongs to the SMAD family. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. SMAD1 mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, SMAD1 can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of SMAD1 forms a complex with SMAD4, which is important for its function in the transcription regulation. SMAD1 is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation.The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.
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Human Bone Morphogenetic Protein 15 (BMP-15/GDF-9B) ELISA Kit
Supplier: AFG BIOSCIENCE LLC
Human Bone Morphogenetic Protein 15 (BMP-15/GDF-9B) ELISA Kit
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Porcine BMP-4 ELISA Kit
Supplier: ANTIBODIES.COM LLC
This Porcine BMP-4 ELISA kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of Porcine BMP-4.
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Rat Bone Morphogenetic Protein 6 (BMP-6) ELISA Kit
Supplier: AFG BIOSCIENCE LLC
Rat Bone Morphogenetic Protein 6 (BMP-6) ELISA Kit
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Human Recombinant BMP5 (from CHO cells)
Supplier: Prosci
TGF-β family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis. As implied by their name, BMPs initiate, promote, and regulate the development, growth and remodeling of bone and cartilage. In addition to this role, BMPs are also involved in prenatal development and postnatal growth, remodeling and maintenance of a variety of other tissues and organs. BMP-5 is expressed in the nervous system, lung and liver. It is a known regulator for dendritic growth in sympathetic neurons. BMP-5 is a 454 amino acid precursor protein that is cleaved to release the biologically active C-terminal mature protein. Recombinant human BMP-5 is a 15.6 kDa homodimeric disulfide-linked protein consisting of two identical 138 amino acid chains.