1653 Results for: "assay 11-50"

Supplier: Genetex

Rat monoclonal [YFC118.3] to Human CD18 ( IgG )

Supplier: CUBE BIOTECH

HighSpec Rho1D4 MagBeads are a suspension of 30 µm magnetic agarose beads coupled to an anti-Rho1D4 antibody.

Supplier: Prosci

Tonsil tissue lysate was prepared by homogenization in lysis buffer (10 mM HEPES pH7.9, 1.5 mM MgCl₂, 10 mM KCl, 1 mM ethylenediaminetetraacetic acid, 10% glycerol, 1% NP-40, and a cocktail of protease inhibitors)

Supplier: Prosci

Uterus tissue lysate was prepared by homogenization in lysis buffer (10 mM HEPES pH7.9, 1.5 mM MgCl₂, 10 mM KCl, 1 mM ethylenediaminetetraacetic acid, 10% glycerol, 1% NP-40, and a cocktail of protease inhibitors)

Supplier: Genetex

Purity: Immunogen affinity purified Species Reactivity: Human, Mouse, Rat Tested Applications: IHC-P, WB Pkg Size: 500 ul

Supplier: Genetex

Platelet-activating factor (PAF) is a biologically active phospholipid with diverse biologic effects. PAF is degraded to inactive products by hydrolysis of the acetyl group at the sn2 position to produce the biologically inactive products LYSO PAF and acetate. This reaction is catalyzed by PAF acetylhydrolase (PAFAH). The various monomeric and multimeric forms of the enzyme are composed of alpha, beta, and gamma PAFAH subunits. The catalytic activity of the enzyme resides in the beta and gamma subunits, whereas the alpha subunit has regulatory activity. Trimer formation is not essential for the catalytic activity.

Supplier: Genetex

Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor and is involved in regulating growth hormone release from the pituitary. It has an appetite stimulating effect, induces adiposity, and stimulates gastric acid secretion, and it is involved in growth regulation. Ghrelin is synthesized as a preprohormone, then proteolytically processed to yield a 28 amino acid peptide. An interesting and unique modification is imposed on the hormone during synthesis in the form of an n octanoic acid bound to one of its amino acids. This modification is necessary for biologic activity.

Supplier: Genetex

Rat monoclonal antibody [M1/70.15] to CD11b

Supplier: Sekisui Diagnostics

This variety of hCG testing kits and procedures allows users to select the method that best suits the facility in use.

Supplier: Genetex

Rb is a tumor suppressor gene which functions as a negative regulator of the cell cycle by interacting with transcription factors including E2F 1, PU 1, ATF 2, UBF, Elf 1 and c-Abl. This ability to alter transcription is regulated by phosphorylation catalyzed by the cyclin-dependent protein kinases (cdks). Phosphorylation of serine 612 is catalyzed by cdk 2 complexes such as Cyclin E-cdk 2 and Cyclin A-cdk 2. Rb contains at least 16 consensus sequences for cdk phosphorylation, but the significance of all of these sites is unclear. Phosphorylation of this site as well as serines 780, 807, and 811 disrupts binding to E2F.

Supplier: Genetex

May appear as a doublet due to phosphorylation. May be used to precipitate active Src which can then be used in a kinase reaction.

Supplier: Prosci

Ovary tissue lysate was prepared by homogenization in lysis buffer (10 mM HEPES pH7.9, 1.5 mM MgCl₂, 10 mM KCl, 1 mM ethylenediaminetetraacetic acid, 10% glycerol, 1% NP-40, and a cocktail of protease inhibitors)

Supplier: Shenandoah Biotechnology

Eotaxin-1, also known as Eotaxin and CCL11, is a chemokine that recruits eosinophils to sites of allergic inflammation. Eotaxin-1 signals through the G protein-coupled chemokine receptors CCR2, CCR3, and CCR5. Eotaxin-1 also negatively regulates adult neurogenesis, and high Eotaxin-1 levels are associated with impaired learning and memory.

Supplier: Biotium

MitoView™ dyes are fluorogenic mitochondrial stains for live cells. The dyes rapidly accumulate in mitochondria and can be imaged without washing. They are available with blue, green, far-red, and near-infrared fluorescence.

Supplier: Prosci

Polyclonal, Host: Chicken, Species Reactivity: Human, Bovine, Immunogen: Human and mouse DHHC5 peptide aa245-261, Tested Applications: ELISA, Western blotting, Immuno histochemistry, Immunocytochemistry, IP

Supplier: Genetex

Mouse monoclonal [W3-13 HLK] to CD43

Supplier: Genetex

Rabbit Polyclonal antibody to TLR4 (toll-like receptor 4) Purity: Protein A purified Species Reactivity: Human Mouse Tested Applications: FACS ICC/IF IHC-P IHC-Fr WB Pkg Size: 100 ug

Supplier: Genetex

Rat monoclonal antibody [YTH34.5] to CD52

Supplier: Shenandoah Biotechnology

Basic fibroblast growth factor (bFGF), also known as FGF2, is expressed by endothelial cells and is a mediator of angiogenesis. bFGF also has cardioprotective functions during heart injury. bFGF binds heparin in order to signal through fibroblast growth factor (FGF) receptor tyrosine kinases.

Supplier: Shenandoah Biotechnology

Basic fibroblast growth factor (bFGF), also known as FGF2, is expressed by endothelial cells and is a mediator of angiogenesis. bFGF also has cardioprotective functions during heart injury. bFGF binds heparin in order to signal through fibroblast growth factor (FGF) receptor tyrosine kinases.

Supplier: Genetex

Psoriasin/HID-5 was originally identified as an up-regulated protein in psoriatic keratinocytes. Subsequently, this protein was found to have elevated expression in abnormally differentiating primary keratinocytes and in various carcinomas, including ductal carcinoma in situ. Psoriasin/HID-5 may play a role in the establishment or maintenance of these pathologies, and may serve as a diagnostic marker of particular tumour types or abnormally proliferative epithelia.

Supplier: CUBE BIOTECH

Synthetic copolymers are capable of solubilizing and stabilizing membrane proteins without the need for detergents. They have the unique capacity to extract the membrane protein of interest while maintaining a near-native environment.

Supplier: Prosci

ZNF322 contains four exons and spans 23.2kb in chromosome 6p22.1 region, and transcribes a 2.7kb mRNA that encodes a protein with 402 amino acid residues.Through northern blot analysis, ZNF322 was shown to be expressed in every human tissue examined at adult stage and during embryonic developmental stages from 80 days to 24 weeks. When ZNF322 was overexpressed in COS-7 cells, ZNF322-EGFP fusion protein is detected in the nucleus and cytoplasm. Reporter gene assays show that ZNF322 is a transcriptional activator. Furthermore, overexpression of ZNF322 in COS-7 cells activates the transcriptional activity of SRE and AP-1. Together, these results suggest that ZNF322 is a member of the zinc-finger transcription factor family and may act as a positive regulator in gene transcription mediated by the MAPK signaling pathways.

Supplier: CUBE BIOTECH

Sensory rhodopsin-2 (SR-2) from N. pharaonis is a 7-transmembrane protein that acts as a phototaxis receptor in archaebacteria.

Supplier: Genetex

Mouse monoclonal [2C1] to ATM (supernatant)

Supplier: Genetex

Members of the 14-3-3 family of proteins are highly conserved proteins, localized in neurons, and are axonally transported to the nerve terminals. They are also present, at lower levels, in various other eukaryotic tissues. 14-3-3 proteins appear to play important roles in a variety of signal transduction pathways, including those involved in cell cycle regulation and cell survival. Because 14-3-3 proteins bind to specific phosphoserine-containing sequences they are likely to have an important role in signaling pathways mediated by serine/threonine protein kinases. Evidence indicates 14-3-3 is required for Raf-1 kinase activity and phosphorylation amoung many other functions.

Supplier: Prosci

ZNF322 contains four exons and spans 23.2kb in chromosome 6p22.1 region, and transcribes a 2.7kb mRNA that encodes a protein with 402 amino acid residues.Through northern blot analysis, ZNF322 was shown to be expressed in every human tissue examined at adult stage and during embryonic developmental stages from 80 days to 24 weeks. When ZNF322 was overexpressed in COS-7 cells, ZNF322-EGFP fusion protein is detected in the nucleus and cytoplasm. Reporter gene assays show that ZNF322 is a transcriptional activator. Furthermore, overexpression of ZNF322 in COS-7 cells activates the transcriptional activity of SRE and AP-1. Together, these results suggest that ZNF322 is a member of the zinc-finger transcription factor family and may act as a positive regulator in gene transcription mediated by the MAPK signaling pathways.

Supplier: Shenandoah Biotechnology

Galectin-1 belongs to the lectin family of carbohydrate binding proteins and binds glycans as both a monomer and a homodimer. Galectin-1 is produced in peripheral lymphoid organs and inflammatory sites. Galectin-1 plays important roles in acute and chronic inflammatory processes, cell growth, cell proliferation, and induces apoptosis of activated T cells. Galectin-1 also modulates cytokine secretion and inhibits pro-inflammatory cytokine production.

Supplier: Thermo Scientific

Built on the foundation of 60 years of spectroscopy experience, the next generation Thermo Scientific GENESYS family of Vis/UV-Vis spectrophotometers provides exceptional performance with a contemporary design.

Supplier: Genetex

In response to adverse changes in their environment, cells from many organisms increase the expression of a class of proteins referred to as heat shock or stress proteins. One class of stress proteins, termed the ""small heat shock proteins"" is comprised of a diverse group of proteins from ~15 to >30kDa, with a single form found in yeast and human cells and multiple related forms found in higher plants. A direct relationship between elevated stress protein expression and neoplasia has been suggested from studies on estrogen-induced proteins in breast cancer cells. In addition, Hsp27 exhibits rapid increased phosphorylation in response to various mitogens, tumor promoters (e.g. phorbol esters) and calcium ionophores. The expression of a 24kDa protein was shown to correlate with steroid hormone receptors in cell lines, organs , and tumors. The 24kDa estrogen-induced protein was found to be expressed at high levels in carcinoma of the breast. Another study has suggested that the levels of Hsp27 correlate with endometrial adenocarcinomas. Interestingly, the regulation of human Hsp27 by estrogens and heat shock is reminiscent of the ecdysteroid and heat shock activation of the drosophila Hsp20 genes.