1636 Results for: "Peprotech"

Supplier: Peprotech

SPARC/Osteonectin is a secreted, evolutionarily-conserved, collagen-binding glycoprotein that is involved in a variety of cellular activities. It is highly expressed in tissues undergoing morphogenesis, remodeling and wound repair. SPARC/Osteonectin and its related peptides bind to numerous proteins of the extracellular matrix (ECM), affect ECM protein expression, influence cellular adhesion and migration, and modulate growth factor-induced cell proliferation and angiogenesis. SPARC/Osteonectin consists of three domains: an N-terminal acidic region that binds calcium ions with low affinity, a module containing two EF-hand motifs that bind calcium with high affinity, and a cysteine-rich follistatin-like domain. Recombinant Human SPARC/Osteonectin is a glycoprotein containing 286 amino acids that migrates at an apparent MW of 43.7 kDa by SDS-PAGE analysis due to the effect of glycosylation. The calculated molecular weight of Recombinant Human SPARC/Osteonectin is 32.7 kDa.

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IL-9 is an immunoregulatory cytokine produced by IL-2 activated Th2 lymphocytes. IL-9 enhances the proliferation of T lymphocytes, mast cells, erythroid precursor cells and megakaryoblastic leukemia cell lines. Over-expression of IL-9 has been implicated in the pathogenesis of anaplastic lymphoma and Hodgkin’s disease. Recombinant Rat IL-9 is a 14.3 kDa protein of 127 amino acid residues, including 10 cysteine residues that are fully conserved between the human and murine proteins.

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Murine C10 belongs to the CC chemokine family and is expressed in myelopoietic bone marrow cultures when stimulated with GM-CSF, M-CSF, IL-3 or IL-4. It signals primarily through the CCR1 receptor. C10 is chemotactic for B cells, CD4+ T cells, monocytes and NK cells and also exhibits powerful suppressive activity on colony formation by different lineages of hematopoietic progenitors. The C10 contains the four highly conserved cysteine residues present in CC chemokines. The mature protein contains 95 amino acid residues. Recombinant Murine C10 (CCL6) is a 10.7 kDa protein containing 95 amino acid residues.

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IL-3 is a hematopoietic growth factor that promotes the survival, differentiation and proliferation of committed progenitor cells of the megakaryocyte, granulocyte-macrophage, erythroid, eosinophil, basophil and mast cell lineages. Produced by T cells, mast cells and eosinophils, IL-3 enhances thrombopoiesis, phagocytosis, and antibody-mediated cellular cytotoxicity. Its ability to activate monocytes suggests that IL-3 may have additional immunoregulatory roles. Many of the IL-3 activities depend upon co-stimulation with other cytokines. IL-3 is a species-specific, variably glycosylated cytokine. Recombinant Human IL-3 is a 15.0 kDa globular protein containing 133 amino acid residues.

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IL-3 is a hematopoietic growth factor that promotes the survival, differentiation and proliferation of committed progenitor cells of the megakaryocyte, granulocyte-macrophage, erythroid, eosinophil, basophil and mast cell lineages. Produced by T cells, mast cells and eosinophils, IL-3 enhances thrombopoiesis, phagocytosis, and antibody-mediated cellular cytotoxicity. Its ability to activate monocytes suggests that IL-3 may have additional immunoregulatory roles. Many of the IL-3 activities depend upon co-stimulation with other cytokines. IL-3 is a species-specific, variably glycosylated cytokine. Recombinant Murine IL-3 is a 15.1 kDa globular protein containing 135 amino acid residues.

Supplier: Peprotech

Produced from sera of goats immunized with highly pure Recombinant Human MCP-3 (CCL7). Anti­Human MCP-3 (CCL7)­specific antibody was purified by affinity chromatography employing an immobilized Human MCP-3 matrix.

Supplier: Peprotech

Produced from sera of rabbits immunized with highly pure Recombinant Human IL-2. Anti­Human IL-2­specific antibody was purified by affinity chromatography and then biotinylated.

Supplier: Peprotech

Produced from sera of rabbits immunized with highly pure Recombinant Human GCP-2 (CXCL6). Anti­Human GCP-2 (CXCL6)­specific antibody was purified by affinity chromatography and then biotinylated.

Supplier: Peprotech

Produced from sera of goats immunized with highly pure Recombinant Human MIP-5 (CCL15). Anti­Human MIP-5 (CCL15)­specific antibody was purified by affinity chromatography and then biotinylated.

Supplier: Peprotech

Produced from sera of goats immunized with highly pure Recombinant Murine TNF-α. Anti­Murine TNF-α­specific antibody was purified by affinity chromatography employing an immobilized Murine TNF-α matrix.

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Produced from sera of rabbits immunized with highly pure Recombinant Murine MCP-5 (CCL12). Anti­Murine MCP-5 (CCL12)­specific antibody was purified by affinity chromatography and then biotinylated.

Supplier: Peprotech

Produced from sera of rabbits immunized with highly pure Recombinant Murine sRANK Ligand. Anti­Murine sRANK Ligand­specific antibody was purified by affinity chromatography employing an immobilized Murine sRANK Ligand matrix.

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Produced from sera of rabbits immunized with highly pure Recombinant Human ENA-78 (CXCL5). Anti­Human ENA-78 (CXCL5)­specific antibody was purified by affinity chromatography employing an immobilized Human ENA-78 matrix.

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Produced from sera of rabbits immunized with highly pure Recombinant Human IL-17E. Anti­Human IL-17E­specific antibody was purified by affinity chromatography and then biotinylated.

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Produced from sera of rabbits immunized with highly pure Recombinant Human IP-10 (CXCL10). Anti­Human IP-10 (CXCL10)­specific antibody was purified by affinity chromatography employing an immobilized Human IP-10 matrix.

Supplier: Peprotech

Produced from sera of goats immunized with highly pure Recombinant Human SDF-1β (CXCL12). Anti­Human SDF-1β (CXCL12)­specific antibody was purified by affinity chromatography employing an immobilized Human SDF-1β matrix.

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ApoE belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. In addition to facilitating solubilization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism. Significant quantities of ApoE are produced in the liver and brain, and to some extent in almost every organ. ApoE is an important constituent of all plasma lipoproteins. Its interaction with specific ApoE receptor enables uptake of chylomicron remnants by liver cells, which is an essential step during normal lipid metabolism. It also binds with the LDL receptor (apo B/E). Defects in ApoE are a cause of hyperlipoproteinemia type III. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. E3 is the most common isoform and is present in 40-90% of the population. Recombinant Human ApoE3 is a 34.4 kDa protein containing 300 amino acid residues.

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GDNF is a disulfide-linked, homodimeric neurotrophic factor structurally related to Artemin, Neurturin and Persephin. These proteins belong to the cysteine-knot superfamily of growth factors that assume stable dimeric protein structures. GDNF signals through a multicomponent receptor system, composed of a RET and one of the four GFRα (α1-α4) receptors. GDNF specifically promotes dopamine uptake and survival, and morphological differentiation of midbrain neurons. Using a Parkinson’s disease mouse model, GDNF has been shown to improve conditions such as bradykinesia, rigidity, and postural instability. The functional human GDNF ligand is a disulfide-linked homodimer consisting of two 15 kDa polypeptide chains called monomers. Each monomer contains seven conserved cysteine residues, including Cys-101, which is used for inter-chain disulfide bridging, and others that are involved in the intramolecular ring formation known as the cysteine knot configuration. The calculated molecular weight of Recombinant Human GDNF is 30.4 kDa.

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Produced from sera of rabbits immunized with highly pure Recombinant Human CTGF . Anti­Human CTGF ­specific antibody was purified by affinity chromatography and then biotinylated.

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Produced from sera of rabbits immunized with highly pure Recombinant Human BD-1. Anti­Human BD-1­specific antibody was purified by affinity chromatography employing an immobilized Human BD-1 matrix.

Supplier: Peprotech

IL-3 is a hematopoietic growth factor that promotes the survival, differentiation and proliferation of committed progenitor cells of the megakaryocyte, granulocyte-macrophage, erythroid, eosinophil, basophil and mast cell lineages.  Produced by T cells, mast cells and eosinophils, IL-3 enhances thrombopoiesis, phagocytosis, and antibody-mediated cellular cytotoxicity.  Its ability to activate monocytes suggests that IL-3 may have additional immunoregulatory roles.  Many of the IL-3 activities depend upon co-stimulation with other cytokines.  IL-3 is a species-specific, variably glycosylated cytokine.  Recombinant Human IL-3 is a 15.0 kDa globular protein containing 133 amino acid residues.Manufactured using all Animal-Free reagents.

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IL-1α is a non-secreted, proinflammatory cytokine produced in a variety of cells, including monocytes, tissue macrophages, keratinocytes, and other epithelial cells. Both IL-1α and IL-1β bind to the same receptor and have similar, if not identical, biological properties. These cytokines have a broad range of activities including the stimulation of thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine. Recombinant Human IL-1α is an 18.0 kDa protein containing 159 amino acid residues.

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Produced from sera of rabbits immunized with highly pure Recombinant Human IL-1RA. Anti­Human IL-1RA­specific antibody was purified by affinity chromatography and then biotinylated.

Supplier: Peprotech

Produced from sera of rabbits immunized with highly pure Recombinant Human/Murine/Rat BMP-2. Anti­Human/Murine/Rat BMP-2­specific antibody was purified by affinity chromatography employing an immobilized Human/Murine/Rat BMP-2 matrix.

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Produced from sera of rabbits immunized with highly pure Recombinant Human BMP-7. Anti­Human BMP-7­specific antibody was purified by affinity chromatography and then biotinylated.

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Produced from sera of rabbits immunized with highly pure Recombinant Human Follistatin. Anti­Human Follistatin­specific antibody was purified by affinity chromatography and then biotinylated.

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Produced from sera of rabbits immunized with highly pure Recombinant Human PDGF-BB. Anti­Human PDGF-BB­specific antibody was purified by affinity chromatography and then biotinylated.

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Produced from sera of rabbits immunized with highly pure Recombinant Human M-CSF. Anti­Human M-CSF­specific antibody was purified by affinity chromatography and then biotinylated.

Supplier: Peprotech

Produced from sera of rabbits immunized with highly pure Recombinant Human SCF. Anti­Human SCF­specific antibody was purified by affinity chromatography employing an immobilized Human SCF matrix.

Supplier: Peprotech

Both MIP-1α and MIP-1β are structurally and functionally related CC chemokines. They participate in host response to invading bacterial, viral, parasite and fungal pathogens, by regulating the trafficking, and activation state, of selected subgroups of inflammatory cells (e.g. macrophages, lymphocytes and NK cells). While both MIP-1α and MIP-1β exert similar effects on monocytes, their effect on lymphocytes differ; with MIP-1α selectively attracting CD8+ lymphocytes, and MIP-1β selectively attracting CD4+ lymphocytes. Additionally, MIP-1α and MIP-1β have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1α and MIP-1β are active on human and murine hematopoietic cells. Recombinant Human MIP-1β (CCL4) is a 7.6 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.