1119 Results for: "Genscript"

Supplier: Genscript

GenScript Mouse Anti-Human IgG Fab Antibody (12H3C4A6)[HRP], mAb reacts with the Fab portion of human IgG but not with the Fc portion of human IgG. The monoclonal antibody has no cross-reactivity with mouse, rat, rabbit, chicken or goat immunoglobulins.

Supplier: Genscript

GenScript MonoRab™ DYKDDDDK tag antibody, mAb, rabbit specifically recognizes DYKDDDDK tags placed at C-terminal, N-terminal and internal regions of DYKDDDDK fusion proteins.

Supplier: Genscript

The product is specific for Rituximab. This antibody serves as an excellent positive control for Rituximab immunogenicity (ADA) assays.

Supplier: Genscript

Eculizumab with trade name Soliris, is an FDA-approved drug to treat paroxysmal nocturnal hemoglobinuria (PNH), atypical hemolytic uremic syndrome (aHUS), and neuromyelitis optica. Eculizumab is a recombinant humanized monoclonal antibody against the complement protein C5. Eculizumab specifically binds to the terminal complement component 5 or C5. Binding to this protein prevents the activation of a complement terminal complex, which is used to treat a number of autoimmune conditions.Anti-Eculizumab Antibody (13F5), mAb, mouse is produced from a hybridoma resulting from the fusion of partner and B-lymphocytes obtained from a mouse immunized with eculizumab.

Supplier: Genscript

A camelid single-domain antibody (sdAb, called Nanobody by Ablynx, the developer) is a peptide chain of about 110 amino acids long, comprising one variable domain of a heavy-chain antibody, these are called VHH fragments. Like a whole antibody, it is able to bind selectively to a specific antigen. Single-domain antibodies allow a broad range of applications in biotechnical as well as therapeutic uses due to their small size, simple production, and high affinity. However, their sequences may increase the risk of immunogenicity and anti-drug antibody (ADA) development in humans, and thus, sdAbs are routinely humanized during development.

Supplier: Genscript

Secukinumab with brand name Cosentyx, is a human IgG1κ monoclonal antibody that binds to the protein interleukin (IL)-17A, and is marketed by novartis for the treatment of psoriasis, ankylosing spondylitis, and psoriatic arthritis. Secukinumab inhibits a member of the cytokine family, interleukin 17A, which is produced mainly by inflammatory T helper 17 cells. IL17A is upregulated in serum of people with psoriasis and in the synovial fluid of people with psoriatic arthritis, and promotes inflammation when it binds to the interleukin-17 receptor. Anti-Secukinumab antibody (23E11), mAb, mouse is produced from a hybridoma resulting from the fusion of partner and B-lymphocytes obtained from a mouse immunized with Secukinumab.

Supplier: Genscript

Bevacizumab (Avastin) is a humanized monoclonal antibody that is approved by the U.S. Food and Drug Administration for the treatment of a number of types of cancers and a specific eye disease. Bevacizumab binds to a continuous epitope in VEGF, preventing interaction of VEGF with VEGFR on the surface of endothelial cells. It can be used to inhibit solid tumours growth and metastasis by weakening tumour angiogenesis.

Supplier: Genscript

The product is specific for daratumumab.

Supplier: Genscript

The antibody is recommended as a detection antibody in a pharmacokinetic (PK) bridging assay with capture antibody GenScript, A01987-40, MonoRab anti-nivolumab antibody (33H4), mAb, rabbit.

Supplier: Genscript

Infliximab with the brand name of Remicade, is a chimeric monoclonal IgG1 antibody. It binds to TNF-alpha, which is a key proinflammatory cytokine involved in chronic inflammatory diseases. Infliximab functions as TNF-alpha blocker to disrupt the interaction of TNF-alpha with its receptors. GenScript Anti-Infliximab Antibody, pAb, Rabbit is produced from sera of a rabbit immunized with Infliximab.

Supplier: Genscript

Adeno-associated virus (AAV) is a single-stranded DNA virus that commonly infects humans without pathology. Therefore, AAV can be engineered to deliver DNA to target cells as a vector for gene therapy. There are several serotypes including AAV type 1, 2, 5, 6, 8, 9, DJ and rh.1. Among them, AAV2 is the best characterized and most commonly used. Cap gene of AAV gives rise to three capsid proteins, VP1, VP2 and VP3, with molecular weight of 87, 72 and 62 kDa respectively. These capsid proteins assemble into a near-spherical protein shell of 60 subunits for AAV.

Supplier: Genscript

CD8 (cluster of differentiation 8) is a member of the immunoglobulin superfamily found on the majority of thymocytes, a subset of peripheral blood T cells, and NK cells (which express almost exclusively CD8a homodimers). CD8 antigen is existed as a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. CD8 acts as a co-receptor with MHC class I-restricted T cell receptors in antigen recognition and T cell activation and has been shown to play a role in thymic differentiation. CD8+ cytotoxic T cells are crucial for the killing of virus-infected cells and tumor cells.

Supplier: Genscript

Adeno-associated virus type 8 (AAV8) is a valuable vector for gene therapy. It is one member of the human parvovirus family which depends on co-infection with helper viruses such as adenovirus or herpes virus for efficient reproduction. AAV8 empty capsids are composed of three proteins, VP1, VP2 and VP3 with relative molecular masses of 87, 72 and 62 kDa respectively.

Supplier: Genscript

GenScript Streptavidin Antibody is specific to streptavidin.

Supplier: Genscript

THE™ c-Myc Tag antibody, mAb, Mouse recognizes C-terminal, N-terminal and internal c-Myc tagged fusion proteins expressed in prokaryotic or eukaryotic cells. It also recognizes c-Myc protein in human cancers or cell lines such as Hela cell lysates.

Supplier: Genscript

THE™ DYKDDDDK Tag antibody, mAb, Mouse recognizes DYKDDDDK; tags localized at the C-terminal, N-terminal and internal region of DYKDDDDK
tagged fusion proteins.

Supplier: Genscript

The product is specific for Bevacizumab. The antibody is recommended as a detection antibody in a pharmacokinetic (PK) bridging assay with capture antibody GenScript, A01975-40, Anti-Bevacizumab Antibody (4H1), mAb, Mouse.

Supplier: Genscript

GenScript MonoRab™ Rabbit Anti-Camelid VHH Cocktail [iFluor 647] is specific for Camelid VHH antibody (Llama, Alpaca and Camel). It has no cross-reactivity with mouse, rat, rabbit, goat or human immunoglobulins.

Supplier: Genscript

The antibody is recommended as a capture antibody in a pharmacokinetic (PK) bridging assay with detection antibody GenScript, A02007-40, MonoRab™ anti-pembrolizumab antibody (47E5), mAb, rabbit.

Supplier: Genscript

The product is specific for Rituximab. The antibody is recommended as a capture antibody in a pharmacokinetic (PK) bridging assay with detection antibody GenScript, A01944-40, MonoRab™ Anti-Rituximab Antibody (194D7) [Biotin], mAb, Rabbit.

Supplier: Genscript

The product is specific for Cetuximab. This antibody can’t block Cetuximab binding with EGFR (Z03202, EGFR, His, Human) in ELISA. The antibody is recommended as a capture antibody in a pharmacokinetic (PK) bridging assay with detection antibody GenScript, A01938-40, Anti-Cetuximab Antibody (18D5), mAb, Mouse.

Supplier: Genscript

The product is specific for Nivolumab. The antibody is recommended as a detection antibody in a pharmacokinetic (PK) bridging assay with capture antibody GenScript, A01847-40, Anti- Nivolumab Antibody (8G6G3D8), mAb, Mouse.

Supplier: Genscript

GenScript MonoRab™ Rabbit Anti-Camelid VHH Cocktail [FITC] is specific for Camelid VHH antibody (Llama, Alpaca and Camel). It has no cross-reactivity with mouse, rat, rabbit, goat or human immunoglobulins.

Supplier: Genscript

The product is specific for daratumumab.

Supplier: Genscript

The product is specific for tocilizumab. The antibody is recommended as a detection antibody in a pharmacokinetic (PK) bridging assay with capture antibody GenScript, A01978-40, anti-tocilizumab antibody (14B10), mAb, mouse.

Supplier: Genscript

Mouse IgG1 control (whole molecule), purified is suitable to be used as control, standard, blocking agent, or coating protein in a variety of assays, including ELISA, FACS, ICC immunoblotting, dot blot, western blot, immunoprecipitation, immunodiffusion, and immunoelectrophoresis. It may also be used as antigen or ligand in immunochemical conjugation reaction. GenScript Mouse IgG1 control (whole molecule), purified is highly purified from culture supernatant from roller bottle through protein A affinity column.GenScript mouse IgG1 control (whole molecule), purified is produced from the hybridoma resulting from fusion of SP2/0-Ag14 myeloma and B-lymphocytes.

Supplier: Genscript

The product is specific for SARS-CoV-2 Spike Protein S1 subunit and its RBD domain.

Supplier: Genscript

Rabbit IgG control is suitable for use as control, standard, blocking agent, or coating protein in a variety of assays, including ELISA, western blot, immunoprecipitation, immunodiffusion, and immunoelectrophoresis, flow cytometry and immunofluorescence. GenScript MonoRab™ rabbit IgG control [iFluor 555] (whole molecule), mAb is iFluor 555 conjugated MonoRab™ rabbit IgG control (whole molecule), mAb.

Supplier: Genscript

The product is specific for sarilumab. The antibody is recommended as a detection antibody in a pharmacokinetic (PK) bridging assay with capture antibody GenScript, A02042-40, anti-sarilumab antibody (26B10), mAb, mouse.

Supplier: Genscript

The product is specific for infliximab. The antibody is recommended as a detection antibody in a pharmacokinetic (PK) bridging assay with capture antibody GenScript, A02040-40, anti-infliximab antibody (27A4), mAb, mouse.