507 Résultats pour : « Diagnostic Biosystems »

Supplier: Diagnostic Biosystems

Treponema pallidum is the causative agent of syphilis. It is a gram negative spirochete, a helical to sinusoidal bacterium with outer and cytoplasmic membranes, a thin peptidoglycan layer, and periplasmic flagella.

Supplier: Diagnostic Biosystems

This antibody reacts with the heavy chain present in all types of human IgM. It stains B cell follicles in human lymphoid tissues. In lymphoid tissues, IgM containing plasma cells stain strongly but immune complexes are usually undetectable.

Supplier: Diagnostic Biosystems

The antibody is specific against human α-1-antitrypsin. This antibody stains macrophages in human tissues and does not stain any other cell type.

Supplier: Diagnostic Biosystems

This antibody reacts with HSV type I specific antigens and with antigens common to HSV type I and II virus. It reacts with all the major glycoproteins present in the viral envelope as well as with at least one core protein.

Supplier: Diagnostic Biosystems

Cyclin D1 belongs to the Cyclin D family. Cyclin D1 is required for the cell cycle G1/S transition. Amplification or overexpression of Cyclin D1 plays a pivotal role in the development of various human cancers including breast cancer, colon cancer, melanoma, prostate cancer and lymphoma. It is useful to differentiate mantle cell lymphoma from small cleaved cell lymphoma. Rabbit monoclonal antibodies to Cyclin D1 showed the highest sensitivity to detect this antigen in formalin fixed paraffin embedded tissue as compared to several other clones.

Supplier: Diagnostic Biosystems

This antibody recognizes a c-erbB-2 protein, which is a receptor tyrosine kinase of the c-erbB family. It is closely related in structure to the epidermal growth factor receptor. c-erbB-2 oncoprotein is detectable in a subset of breast and other adenocarcinomas, as well as transitional cell carcinomas. In the case of breast cancer, expression determined by immunohistochemistry has been shown to be associated with poor prognosis.

Supplier: Diagnostic Biosystems

This antibody reacts with lysozyme. It stains granulocytes, monocytes and macrophages in human tonsil, skin and colon. This antibody does not cross-react with any other cell types.

Supplier: Diagnostic Biosystems

This antibody is specific to a membrane glycoprotein of 45 kDa, designated as CD23. CD23 is found on a subpopulation of peripheral blood cells, B lymphocytes and on EBV transformed B lymphoblastoid cell lines. Expression of CD23 has been detected in neoplastic cells from cases of B cell chronic lymphocytic leukemias.

Supplier: Diagnostic Biosystems

The caudal-related homeodomain protein 2, CDX-2, is a transcription factor which is expressed in the intestine and is thought to play an important role in the proliferation and differentiation of intestinal epithelial cells. The CDX-2 protein is expressed in primary and metastatic colorectal carcinomas, intestinal metaplasia of the stomach and intestinal type gastric cancer. In human colorectal cancer, the expression of both CDX2 and carbonic anhydrase 1, a gene regulated by CDX2, is reduced or absent. CDX-2 is one of the important regulators in defining pathways for coordinate control of drug metabolism in the gastrointestinal tract.

Supplier: Diagnostic Biosystems

This antibody is specific to γ-γ enolase isozyme of 46 kDa. This antibody stains neurons, neuroendocrine cells, gangliomas, oat cell carcinomas, astrocytomas, paragangliomas, glioblastomas, pheochromocytomas, melanomas and schwannomas.

Supplier: Diagnostic Biosystems

Chromogranin A is a 439 amino acid protein present in secretory granules of a wide variety of endocrine cells and neurons. A positive staining is seen in the secretory granules of parathyroid, adrenal medulla, anterior pituitary gland and Langerhans islets of pancreas. This antibody stains a variety of neuroendocrine tumors.

Supplier: Diagnostic Biosystems

This antibody recognizes keratin polypeptides of 68, 58, 56.5 and 50 kDa in the stratum corneum. The antibody reacts with squamous, ductal and other complex epithelia. It stains adenocarcinomas, breast, pancreas, bile duct, salivary gland and transitional cell carcinomas.

Supplier: Diagnostic Biosystems

This antibody recognizes CD5, which is a transmembrane protein, is found on 95% of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes, the main reactivity is observed in T cell areas. CD5 is expressed by many T cell leukemia, lymphomas, and activated T cells. Occasionally, CD5 antigen is also expressed on a subset of B cells. Mantle cell lymphomas (same as diffuse centrocytic lymphomas) are CD5(+) while the follicle center cell lymphoma are CD5(-).

Supplier: Diagnostic Biosystems

The HMB45 clone reacts with a neuraminidase-sensitive oligosaccharide side chain of a glycoconjugate present in immature melanosomes. The HMB45-reactive antigen is present in cutaneous melanocytes, prenatal and infantile retinal pigment epithelium and melanoma cells and is thought to be oncofetal in nature. This antibody has been shown to label the majority of melanomas. Clone A103 recognizes a protein of 20 kDa, identified as MART-1 (melanoma antigen recognized by T cells-1) or Melan-A. Melan-A is a useful addition to melanoma panels as it is apparently specific for melanocytic lesions. Studies have also shown that MART-1 is more sensitive than HMB45 when labeling metastatic melanomas. Tyrosinase is a key enzyme involved in the initial stages of melanin biosynthesis. Studies have shown tyrosinase to be a more sensitive marker when compared to HMB45 and MART-1. It has been shown to label a higher percentage of desmoplastic melanomas than HMB45. The combination of HMB45, MART-1 and tyrosinase make this triple antibody cocktail a first-order pan melanoma screener.

Supplier: Diagnostic Biosystems

This antibody recognizes human retinoblastoma gene protein. Rb gene, a prototype of tumor suppressor genes, has been associated with development and/or progression of bladder cancer as well as sarcoma and small cell lung cancer. Functional Rb gene loss has been reported to occur in bladder cancer and osteosarcoma. A significantly poorer tumor-free survival rate was noted for those patients who had a tumor with an altered Rb protein with or without vascular invasion.

Supplier: Diagnostic Biosystems

This antibody reacts with free as well as bound kappa light chains. Contaminating antibodies have been removed by solid phase adsorption.

Supplier: Diagnostic Biosystems

Anaplastic lymphoma kinase (ALK) known as ALK tyrosine kinase receptor or CD246, is a tyrosine kinase receptor. ALK is an important biomarker for diagnosis of non-­‐small cell lung cancer (NSCLC).

Supplier: Diagnostic Biosystems

Cytokeratin 20 is less acidic than the other type I cytokeratins and is of particular interest because of its restricted range of expression. This antibody reacts with cytokeratin polypeptide of 46 kDa in immunoblot analyses. Studies have shown that a marked difference exists in the expression of Cytokeratin 20 among various carcinomas.

Supplier: Diagnostic Biosystems

P504S has been recently described as a prostate cancer-specific gene that encodes a protein involved in the β-oxidation of branched chain fatty acids. Expression of p504S protein is found in prostatic adenocarcinoma but not in benign prostatic tissue. It stains premalignant lesions of prostate: high-grade prostatic intraepithelial neoplasia (PIN) and atypical adenomatous hyperplasia. P504S can be used as a positive marker for PIN.

Supplier: Diagnostic Biosystems

The combined detection of p504S, p40 and high molecular weight cytokeratin markers has been shown to be useful for distinguishing benign conditions mimicking cancer from prostate carcinomas. In particular, these markers have been shown to be relevant in diagnosing the premalignant condition, prostatic intraepithelial neoplasia (PIN). High molecular weight cytokeratin and p63 are commonly used markers of basal epithelial cells. Benign prostate tissue contains basal cells, which are absent in prostate cancers. As p40 is an isoform of p63, it also stains basal epithelial cells and can be used in prostate cancer tissue. P504S has been recently described as a prostate cancer-specific gene. Expression of p504S (AMACR) protein is seen in prostatic adenocarcinoma but not in benign prostatic tissue. Anti-p540S stains premalignant lesions of prostate: high-grade PIN and atypical adenomatous hyperplasia. The PIN5 antibody combination may be particularly useful for confirming the diagnosis of prostate carcinoma in small foci of needle biopsies. The positive prostate cancer marker, p504S (AMACR), in conjunction with the negative basal cell markers (p40 and HMW cytokeratin) offers utility in diagnosing PIN in difficult cases where tissue may be limited.

Supplier: Diagnostic Biosystems

This antibody is specific to an epitope on the N-terminus of ACTH. This antibody stains corticotrophs in the adenohypophysis and is useful in the classification of pituitary adenomas.

Supplier: Diagnostic Biosystems

Twenty human keratins are resolved with two-dimensional gel electrophoresis into acidic (pH 6.0) subfamilies. This antibody cocktail recognizes acidic (Type I or LMW) and basic (Type II or HMW) cytokeratins, which 67kDa (CK1); 64kDa (CK3); 59kDa (CK4); 58kDa (CK5); 56kDa (CK6); 52kDa (CK8); 56.5kDa (CK10); 50kDa (CK14); 50kDa (CK15); 48kDa (CK16); 40kDa (CK19). Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis. It is a broad spectrum anti pan-cytokeratin antibody, which differentiates epithelial tumors from non-epithelial tumors e.g., squamous vs. adenocarcinoma of the lung, liver carcinoma, breast cancer, and esophageal cancer. It may be useful to characterize the source of various neoplasms and to study the distribution of cytokeratin containing cells in epithelia during normal development and during the development of epithelial neoplasms. This antibody stains cytokeratins present in normal and abnormal human tissues and has high sensitivity in the recognition of epithelial cells and carcinomas.

Supplier: Diagnostic Biosystems

This antibody recognizes keratin polypeptide of 54 kDa. It stains a number of epithelial cells including ductal and glandular epithelia. Stratified squamous epithelia are positive but transitional epithelium of the urinary tract does not show any staining. This antibody labels adenocarcinomas and transitional carcinomas but does not react with squamous cell carcinomas.

Supplier: Diagnostic Biosystems

This antibody is specific to a 32 kDa protein, which is identified as Caspase 3. Caspase 3 is associated with induction of apoptosis. Caspase 3 is ubiquitously expressed and is synthesized as an inactive proenzyme.

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SUDAN BLACK B KIT 100RXN

Supplier: Diagnostic Biosystems

ANTI MOUSE & RABBIT (HRP)

Supplier: Diagnostic Biosystems

IGG - CLONE A57H .5ML