9550 Résultats pour : « Biotium »

Supplier: Biotium

GelRed™ and GelGreen™ are a new generation of fluorescent nucleic acid gel stains designed to replace the highly toxic ethidium bromide (EtBr)

Supplier: Biotium

is labeled w/deep-red fluorescent dye CF594 which is spectrally similar to Alexa Fluor 594 & Texas Red dyes but yields brighter protein conjugates. CF594 has photostability ideal for demanding applications such as multi-color imaging.

Supplier: Biotium

Conjugates are particULarly usefUL for mULti-color fluorescence staining in combination with our CF350, CF488A, and CF647 conjugates.

Supplier: Biotium

Blue Fluorescent Cf405M (Ex/Em 408/452 Nm) Is Spectrally Similar To Pacific Blue, With Superior Photostability; Antibody Has Minimal Cross-Reactivity To Bovine, Goat, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep, And Syrian Hamster Serum Proteins

Supplier: Biotium

Anti-IgG Donkey Polyclonal Antibody (CF™ 770)

Supplier: Biotium

This conjugate is prepared by labeling F(ab’)2 fragment of goat anti-rabbit IgG (H+L) with CF™647 dye. CF™ dyes offer advantages in brightness, photostability, and specificity compared to other fluorescent dyes. Far-red fluorescent CF™647 (Ex/Em 650/665 nm) is brighter than Cy®5 and an excellent alternative to Alexa Fluor® 647 for antibody conjugates.

Alexa Fluor® is a registered trademark of Thermo Fisher Scientific. Cy®5 is a registered trademark of GE Healthcare.

Supplier: Biotium

CD27 Monoclonal antibody, Clone: 203.6, Host: Mouse, Species reactivity: Human, Isotype: IgG3, kappa, Conjugate: biotin, Immunogen: Sezary cells, Synonyms: T14, TNFRSF7, TNFSF7, Tp55, Application: IF, FC, Size: 500 uL

Supplier: Biotium

CD10 Monoclonal antibody, Clone: FR4D11, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: biotin, Immunogen: Raji cellsUnigene 307734, Application: Immunofluorescence, Flow cytometry, Size: 100uL

Supplier: Biotium

This antibody recognizes a protein of 25-26 kDa, identified as the bcl-2 α oncoprotein. It shows no cross-reaction with Bcl-x or Bax protein. Expression of bcl-2 α oncoprotein inhibits the programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of bcl-2 α protein, whereas the normal or hyperplastic germinal centers are negative. Consequently, this antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies. It may also be used in distinguishing between those follicular lymphomas that express bcl-2 protein and the small number in which the neoplastic cells are bcl-2 negative.

Supplier: Biotium

CGA Monoclonal antibody, Clone: CHGA/765, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF405S, Immunogen: Recom human chromogranin A protein, Synonyms: Beta-Granin, CGA, ER-37, Application: IF, IHC, FC, Size: 100uL

Supplier: Biotium

TAG-72 / CA72.4, Monoclonal antibody, Clone: CC49, Host: Mouse, Species reactivity: Human, Hamster, Dog, Cow, Rat, Isotype: IgG1, kappa, Conjugate: CF405S, Immunogen: Membrane-enriched fraction of breast carcinoma, Synonyms: CA72.4, Size: 100uL

Supplier: Biotium

Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GISTs), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GISTs, including all c-kit negative GISTs. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GISTs is nearly identical: 94.4% vs. 94.7%.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®405S is a blue fluorescent dye (Ex/Em 404/431 nm) with superior brightness compared to other blue dyes; it is also compatible with super-resolution imaging by SIM. Note: Conjugates of blue fluorescent dyes are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Supplier: Biotium

HSP60, Monoclonal antibody, Clone: GROEL/730, Host: Mouse, Species reactivity: Mouse, Hamster, Monkey, Pig, Dog, Cow, Sheep, Rat, Human, Chicken, Rabbit, Isotype: IgG1, kappa, Conjugate: CF405S, Immunogen: Recombinant human HSPD1 protein, Application: IF, Size: 100uL

Supplier: Biotium

Thyroglobulin, Monoclonal antibody, Clone: 6E1, Host: Mouse, Species reactivity: Mouse, Rat, Human, Isotype: IgG1, kappa, Conjugate: CF488A, Immunogen: Human thyroid follicular cells, Synonyms: AITD3, Application: Immunohistology (formalin), Flow cytometry, Size: 500uL

Supplier: Biotium

Von Willebrand Factor, Monoclonal antibody, Clone: 3E2D10, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF640R, Immunogen: Recombinant human vWF fragment spanning aa 845-949, Synonyms: Coagulation Factor VIII, Application: IF, Size: 100uL

Supplier: Biotium

Von Willebrand Factor, Monoclonal antibody, Clone: 3E2D10 + VWF635, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF594, Immunogen: Recombinant human vWF fragment spanning aa 845-949, Synonyms: Coagulation Factor VIII, Size: 100uL

Supplier: Biotium

This antibody recognizes proteins of 80-200 kDa, identified as different members of CEA family. CEA is synthesized during development in the fetal gut and is re-expressed in increased amounts in intestinal carcinomas and several other tumors. This MAb does not react with nonspecific cross-reacting antigen (NCA) and with human polymorphonuclear leucocytes. It shows no reaction with a variety of normal tissues and is suitable for staining of formalin/paraffin tissues. CEA is not found in benign glands, stroma, or malignant prostatic cells. Antibody to CEA is useful in detecting early foci of gastric carcinoma and in distinguishing pulmonary adenocarcinomas (60-70% are CEA positive) from pleural mesotheliomas (rarely or weakly CEA positive) . Anti-CEA positivity is seen in adenocarcinomas from the lung, colon, stomach, esophagus, pancreas, gallbadder, urachus, salivary gland, ovary, and endocervix.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®647 is a far-red fluorescent dye (Ex/Em 650/665 nm) with excellent brightness. It also is compatible with super-resolution imaging by STORM.

Supplier: Biotium

This MAb recognizes a protein of 145 kDa, identified as CD117/p145kit. It is found on a wide variety of tumor cells including follicular and papillary carcinoma of thyroid, adenocarcinomas from endometrium, lung, ovary, pancreas, and breast as well as malignant melanoma, endodermal sinus tumor, and small cell carcinoma. However, anti-CD117 has been particularly useful in differentiating gastrointestinal stromal tumors from Kaposi's sarcoma, tumors of smooth muscle origin, fibromatosis, and neural tumors of the GI tract. Anti-CD117 is also useful in recognizing myeloblasts in bone marrow biopsy and clot section.

Supplier: Biotium

CD10 Monoclonal antibody, Clone: CB-CALLA, Host: Mouse, Species reactivity: Human, Isotype: IgG2b, kappa, Conjugate: biotin, Immunogen: Human CD10Unigene 307734, Application: Immunofluorescence, Flow cytometry, Size: 100uL

Supplier: Biotium

Liver CanuliculI, Monoclonal antibody, Clone: HSA98, Host: Mouse, Species reactivity: Human, Isotype: IgG2b, kappa, Conjugate: biotin, Immunogen: HEP-3B human hepatocellular carcinoma cells, Application: Immunofluorescence, Size: 100uL

Supplier: Biotium

IgG Immunoglobulin, Monoclonal antibody, Clone: IG217, Host: Mouse, Species reactivity: Human, Isotype: IgG's, Conjugate: biotin, Immunogen: Purified polyclonal human Ig Gamma Chain, Application: Immunofluorescence, Immunohistology (formalin), Flow, Size: 500uL

Supplier: Biotium

Human Nuclear Antigen, Monoclonal antibody, Clone: 235-1, Host: Mouse, Species reactivity: Human, Non-human primates, Isotype: IgG1, kappa, Conjugate: CF543, Immunogen: Nuclei of human myeloid leukemia biopsy cells, Synonyms: HNA; HuNu, Application: IF, Size: 500uL

Supplier: Biotium

with the green fluorescent dye CF488A. CF488A is a superior alternative to FITC (or fluorescein) due to its exceptional brightness and photostability. CF488A is comparably bright and photostable to Alexa Fluor 488, and more specific.

Supplier: Biotium

Anti-IgG2a Goat Polyclonal Antibody (CF™ 770)

Supplier: Biotium

Cytokeratin 8 Monoclonal antibody, Clone: B22.1, Host: Mouse, Species reactivity: Rabbit, Pig, Cow, Sheep, Human, Isotype: IgG, K, Conjugate: biotin, Immunogen: Cytoskeletal preparation, Synonyms: CYK8, Application: IF, Size: 500 uL

Supplier: Biotium

This MAb reacts with the rod domain of human cytokeratin-19 (CK19), a polypeptide of 40 kDa. Its epitope maps between amino acid 312-335. CK19 is expressed in sweat gland, mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, and ectocervical epithelium. Anti-CK19 reacts with a wide variety of epithelial malignancies including adenocarcinomas of the colon, stomach, pancreas, biliary tract, liver, and breast. Perhaps the most useful application is the identification of thyroid carcinoma of the papillary type, although 50%-60% of follicular carcinomas are also labeled. Anti-CK19 is a useful marker for detection of tumor cells in lymph nodes, peripheral blood, bone marrow and breast cancer.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®568 is a red fluorescent dye (Ex/Em 562/583 nm) with superior brightness and photostability. It also is compatible with super-resolution imaging by STORM and TIRF.

Supplier: Biotium

CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45RB is expressed on mature B-lymphocytes and the majority of lymphomas and leukemias of B-cell origin.

Supplier: Biotium

This MAb reacts with both SUMO-2 and SUMO-3. The small ubiquitin-related modifier (SUMO) proteins, which include SUMO-1, 2 and 3, belong to the ubiquitin-like protein family. Like ubiquitin, the SUMO proteins are synthesized as precursor proteins that undergo processing before conjugation to target proteins. Also, both utilize the E1, E2 and E3 cascade enzymes for conjugation. However, SUMO and ubiquitin differ with respect to targeting. Ubiquitination predominantly targets proteins for degradation, whereas sumoylation targets proteins to a variety of cellular processing, including nuclear transport, transcriptional regulation, apoptosis and protein stability. The unconjugated SUMO-1, 2 and 3 proteins localize to the nuclear membrane, nuclear bodies and cytoplasm, respectively. SUMO-1 utilizes Ubc9 for conjugation to several target proteins, which include MDM2, p53, PML and RanGap1. SUMO-2 and 3 contribute to a greater percentage of protein modification than does SUMO-1 and unlike SUMO-1, they can form polymeric chains. In addition, SUMO-3 regulates beta-Amyloid generation and may be critical in the onset or progression of Alzheimer’s disease.

Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Supplier: Biotium

Lambda Light Chain, Monoclonal antibody, Clone: LcN-2, Host: Mouse, Species reactivity: Human, Isotype: IgG2a, kappa, Conjugate: biotin, Immunogen: Purified IgG myeloma proteins coupled to polyaminostyren, Synonyms: BJP, Application: IF, Size: 500uL

Supplier: Biotium

CD34 Monoclonal antibody, Clone: HPCA1/763, Host: Mouse, Species reactivity: Human, Isotype: IgG1 and IgG2b, kappa, Conjugate: biotin, Immunogen: Recom full-length human HPCA1 protein, Synonyms: HPCA1, Mucosialin, Application: IF, IHC, FC, Size: 100uL