44219 Results for: "Bioss"
Anti-IL3 Rabbit Polyclonal Antibody (Cy5®)
Supplier: Bioss
The pleiotropic IL3 (Interleukin 3) is a 15kDa cytokine that is primarily secreted by activated T lymphocytes and stimulates the proliferation and differentiation of hematopoietic cells. IL3 acts in hematopoiesis by controlling the production, differentiation, and function of two related white cell populations of the blood, the granulocytes and the monocytes/macrophages. It induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes and is expressed by activated T cells, mast cells, and natural killer cells. IL3 not only supports growth of both pluripotent stem cells and the more differentiated committed progenitors, but it also stimulates the functional activity of some fully differentiated cells. IL3 has also been shown to protect mast cells from undergoing apoptosis.
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Anti-Cellulase Rabbit Polyclonal Antibody (Alexa Fluor® 488)
Supplier: Bioss
Cellulase
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Anti-AURKAIP1 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))
Supplier: Bioss
May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation.
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Anti-AURKAIP1 Rabbit Polyclonal Antibody (Cy7®)
Supplier: Bioss
May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation.
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Anti-hnRNP L Rabbit Polyclonal Antibody
Supplier: Bioss
Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements. Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter.
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Anti-CDC40 Rabbit Polyclonal Antibody (Cy5.5®)
Supplier: Bioss
Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing.
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Anti-CDC40 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))
Supplier: Bioss
Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing.
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Anti-CDC40 Rabbit Polyclonal Antibody
Supplier: Bioss
Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing.
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Anti-CD74 Rabbit Polyclonal Antibody (Alexa Fluor® 555)
Supplier: Bioss
Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.
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Anti-CDC37 Rabbit Polyclonal Antibody (Cy7®)
Supplier: Bioss
Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity.
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Anti-BPI Rabbit Polyclonal Antibody (Cy7®)
Supplier: Bioss
The antimicrobial protein Bactericidal Permeability Increasing protein (BPI) is a 55 kDa protein found in the primary granules of polymorhonuclear leukocytes (PMN). The cytotoxicity action of BPI is limited to gram negative bacteria, reflecting the high affinity of BPI for bacterial LPS. Binding of BPI to live bacteria via LPS causes anti-infective activites: 1) cytotoxicity via sequential damage to bacterial outer and inner lipid membranes, 2) neutralization of gram-negative bacterial LPS, 3) opsonization of bacteria to enhance phagocytosis by neutrophils.
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Anti-BPI Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))
Supplier: Bioss
The antimicrobial protein Bactericidal Permeability Increasing protein (BPI) is a 55 kDa protein found in the primary granules of polymorhonuclear leukocytes (PMN). The cytotoxicity action of BPI is limited to gram negative bacteria, reflecting the high affinity of BPI for bacterial LPS. Binding of BPI to live bacteria via LPS causes anti-infective activites: 1) cytotoxicity via sequential damage to bacterial outer and inner lipid membranes, 2) neutralization of gram-negative bacterial LPS, 3) opsonization of bacteria to enhance phagocytosis by neutrophils.
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Anti-CDC40 Rabbit Polyclonal Antibody (Cy7®)
Supplier: Bioss
Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing.
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Anti-SPRN Rabbit Polyclonal Antibody (Cy3®)
Supplier: Bioss
Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP.
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Anti-Mycobacterium bovis Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))
Supplier: Bioss
Mycobacterium bovis
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Anti-ICAM1 Rabbit Polyclonal Antibody (Cy5.5®)
Supplier: Bioss
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.
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Anti-CARM1 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))
Supplier: Bioss
Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B. Acts as coactivator for PPARG, promotes adipocyte differentiation and the accumulation of brown fat tissue. Plays a role in the regulation of pre-mRNA alternative splicing by methylation of splicing factors. Also seems to be involved in p53/TP53 transcriptional activation. Methylates EP300/P300, both at 'Arg-2142', which may loosen its interaction with NCOA2/GRIP1, and at 'Arg-580' and 'Arg-604' in the KIX domain, which impairs its interaction with CREB and inhibits CREB-dependent transcriptional activation. Also methylates arginine residues in RNA-binding proteins PABPC1, ELAVL1 and ELAV4, which may affect their mRNA-stabilizing properties and the half-life of their target mRNAs.
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Anti-DNM1L Rabbit Polyclonal Antibody (Alexa Fluor® 555)
Supplier: Bioss
Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage. Required for normal brain development, including that of cerebellum. Facilitates developmentally regulated apoptosis during neural tube formation. Required for a normal rate of cytochrome c release and caspase activation during apoptosis; this requirement may depend upon the cell type and the physiological apoptotic cues. Also required for mitochondrial fission during mitosis. Required for formation of endocytic vesicles. Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles; the function may require its recruitment by MFF to clathrin-containing vesicles. Required for programmed necrosis execution. Isoform 1 and isoform 4 inhibit peroxisomal division when overexpressed.
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Anti-HMGCR Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))
Supplier: Bioss
Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.
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Anti-FABP4 Rabbit Polyclonal Antibody (Alexa Fluor® 647)
Supplier: Bioss
Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity).
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Anti-MYL9 Rabbit Polyclonal Antibody
Supplier: Bioss
Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion.
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Anti-MYL9 Rabbit Polyclonal Antibody (Cy7®)
Supplier: Bioss
Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion.
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Anti-CBL Rabbit Polyclonal Antibody
Supplier: Bioss
Participates in signal transduction in hematopoietic cells. Adapter protein that functions as a negative regulator of many signaling pathways that start from receptors at the cell surface. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including PDGFA, EGF and CSF1, and terminates signaling.
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Anti-CBL Rabbit Polyclonal Antibody (Alexa Fluor® 350)
Supplier: Bioss
Participates in signal transduction in hematopoietic cells. Adapter protein that functions as a negative regulator of many signaling pathways that start from receptors at the cell surface. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including PDGFA, EGF and CSF1, and terminates signaling.
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Anti-ABL1 Rabbit Polyclonal Antibody (Alexa Fluor® 350)
Supplier: Bioss
The c Abl proto oncogene encodes a protein tyrosine kinase that is located in the cytoplasm and nucleus. In chronic myelogenous leukemia and in a subset of acute lymphoblastic leukemias, the c Abl proto oncogene undergoes a (9;22) chromosomal translocation producing a novel rearranged chromosome (the Philadelphia chromosome) As the result of the fusion of c Abl sequences from chromosome 9 to the Bcr gene on chromosome 22. The molecular consequence of this translocation is the generation of a chimeric Bcr/Abl mRNA encoding activated Abl protein tyrosine kinase.
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Anti-ABL1 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))
Supplier: Bioss
The c Abl proto oncogene encodes a protein tyrosine kinase that is located in the cytoplasm and nucleus. In chronic myelogenous leukemia and in a subset of acute lymphoblastic leukemias, the c Abl proto oncogene undergoes a (9;22) chromosomal translocation producing a novel rearranged chromosome (the Philadelphia chromosome) As the result of the fusion of c Abl sequences from chromosome 9 to the Bcr gene on chromosome 22. The molecular consequence of this translocation is the generation of a chimeric Bcr/Abl mRNA encoding activated Abl protein tyrosine kinase.
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Anti-SPTLC1 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))
Supplier: Bioss
SPTLC1
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Anti-SPTLC1 Rabbit Polyclonal Antibody (Alexa Fluor® 488)
Supplier: Bioss
SPTLC1
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Anti-ASAP1 Rabbit Polyclonal Antibody (Alexa Fluor® 555)
Supplier: Bioss
ADP-ribosylation factor (Arf) family of small GTP-binding proteins plays a central role in membrane trafficking and cytoskeletal remodeling. ASAP1 (Arf-GAP containing SH3, ankyrin repeats and PH domain) is a phospholipid-dependent Arf GTPase-activating protein that binds to the protein-tyrosine kinases Src and focal adhesion kinase. ASAP1 may act as an oncogene in cancer, and it may be a useful diagnostic marker and therapeutic target.