3087 Results for: "Bachem Americas"

Supplier: Bachem Americas

These N-modified peptides are used as standards for the determination of the extent of the N-terminal globin modification in erythrocytes of people exposed to alkylating agents or to triazinyl derivatives. Isolated globin is submitted to Edman degradation and the thiohydantoin derivatives are separated and quantified by GC-MS, with the help of these standards.

Supplier: Bachem Americas

Potent and selective neuropeptide FF (NPFF) receptor antagonist. RF9 (1-Adamantanecarbonyl-Arg-Phe-NH₂) blocked the delayed and long-lasting paradoxical opioid-induced hyperalgesia and prevented the development of associated tolerance. RF9 could also efficiently block the increase in blood pressure and heart rate evoked by NPFF.

Supplier: Bachem Americas

Sequence: H-Pro-NHEt · HCl

Supplier: Bachem Americas

Sequence: H-Cys(SO₃H)-OH · sodium salt

Supplier: Bachem Americas

Sequence: N-Me-Lys-OH

Supplier: Bachem Americas

Sequence: N-Me-Trp-OH
Synonym(s): L-Abrine

Supplier: Bachem Americas

Sequence: H-Glu(OMe)-OtBu · HCl

Supplier: Bachem Americas

Sequence: Aloc-Ala-OH · DCHA

Supplier: Bachem Americas

The bioactive tetrapeptide goralatide which corresponds to the N-terminus of Thymosin β₄, is a physiological regulator of hematopoiesis and inhibits the entry into the S-phase of murine and human hematopoietic stem cells. Ac-SDKP has been shown to reduce the damage to specific compartments in the bone marrow resulting from treatment with chemotherapeutic agents, ionizing radiations, hyperthermy, or phototherapy. It protects from doxorubicin-induced toxicity. Ac-SDKP is a physiological substrate of angiotensin I- converting enzyme (ACE).

Supplier: Bachem Americas

Please see also α-MSH (corresponds to acetyl-ACTH (1-13) amide, H-1075), α-MSH (free acid) (acetyl-ACTH (1-13), H-1070), and (Des-acetyl)-α-MSH (H-4390). Wied: Pituitary Adrenal System Hormones and Behaviour. Symposium on Developments in Endocrinology (1976) / Anon.: ACTH and Related Peptides: Structure, Regulation, and Action. Ann. N.Y. Acad. Sci. 297, 1 (1977) / A.V.Schally: Aspects of Hypothalamic Regulation of the Pituitary Gland. Science 202, 18 (1978) / R.Schwyzer: Studies on Polypeptide Receptors. A Critical View on the Mechanism of ACTH Action. Bull. Schweiz. Acad. Med. Wiss. 34, 263 (1978).

Supplier: Bachem Americas

CNP, a member of the natriuretic peptide family, was first identified in porcine brain and later found in other mammals as well as non-mammals. Processing of the CNP precursor gives rise to CNP-22 and its N-terminally elongated form, CNP-53. The CNPs share considerable sequence homology with ANP and BNP within the disulfide loop and exert similar pharmacological actions, although with different relative potencies. CNP-22 is a potent and selective activator of the human BNP cell surface receptor, a transmembrane guanylyl cyclase. This ligand-receptor pair may be involved in the regulation of fluid homeostasis by the central nervous system.

Supplier: Bachem Americas

The amyloid precursor protein (APP) is cleaved within the amyloid β-protein region by a putative APP secretase to release its extracellular portion. Gelatinase A, the matrix metalloproteinase MMP-2, possesses such APP secretase-like activity, effectively hydrolyzing also the synthetic amyloid β-protein fragment (10-20) YEVHHQKLVFF at the normal processing site, the Lys¹⁶-Leu¹⁷ bond (Km approx. 0.13 mM).

Supplier: Bachem Americas

See also the pTH2 receptor agonist TIP39 (H-4878).

Supplier: Bachem Americas

Antimicrobial peptides are produced by plants and most organisms throughout the animal kingdom including humans. Antimicrobial peptides protect against a broad range of infectious agents, as bacteria, fungi, and viruses. The amphibian skin is an especially rich source of antimicrobial peptides. See also the product families: Hepcidins LL-37 and Fragments Tuftsin and Analogs (subfamily).

Supplier: Bachem Americas

Melanin-concentrating hormone (MCH), originally isolated from salmon pituitary glands, has also been found in the mammalian CNS. In lower vertebrates, salmon MCH alters pigmentation by inducing melanosome aggregation within melanocytes of teleost fish, whereas it causes melanosome dispersion in amphibians and reptiles. The biological role of MCH in higher vertebrates, however, is not yet fully understood, but it may function as a neuromodulator and hypophysiotropic agent in the secretion of α-MSH, ACTH, and GH.

Supplier: Bachem Americas

1G CAS: 37460-22-3 C8H15N3O4 FW: 217.23

Supplier: Bachem Americas

Sequence: H-Asp-AMC

Supplier: Bachem Americas

Z-RLRGG-AMC is a fluorogenic substrate for the deubiquitinating enzyme isopeptidase T (IPaseT) and other ubiquitin C-terminal hydrolases (UCHs) based on the C-termini of ubiquitin with a kcat/Km value of 95 M⁻¹s⁻¹. Together with our product I-1685 it is used in continuous assays for precise mechanistic studies or microtiter plate assays for high-throughput inhibitor screening.

Supplier: Bachem Americas

Sequence: Z-Tyr-Val-Ala-Asp-AFC
Synonym(s): Z-YVAD-AFC

Supplier: Bachem Americas

Substrates for measuring the chymotryptic, PGPH, and tryptic acitivity of the 20S or 26S proteasome. See also the thrombin substrate I-1140.

Supplier: Bachem Americas

PR-AMC, a fluorogenic Plasmodium falciparum dipeptidyl aminopeptidase 1 (DPAP1, cathepsin C) substrate.

Supplier: Bachem Americas

Substrates for measuring the chymotryptic, PGPH, and tryptic acitivity of the 20S or 26S proteasome. See also the thrombin substrate I-1140.

Supplier: Bachem Americas

Z-LR-AMC, a fluorogenic substrate for cathepsin K, L, S, and V, human tissue kallikrein, and the falcipains I - III. Z-LR-AMC is the preferred substrate of falcipain II, a hemoglobin-degrading cysteine protease from Plasmodium falciparum, one of the most promising targets for antimalarial drug design.

Supplier: Bachem Americas

See also Boc-Lys(Ac)-AMC (I-1875) and Boc-Lys(Tfa)-AMC (I-1985).

Supplier: Bachem Americas

LHRH is also called Gonadotropin-Releasing Hormone (GnRH) or Luteinizing Hormone-Releasing Factor (LRF).

Supplier: Bachem Americas

Endothelins are peptides with exceptional vasoconstrictor potency. They play an important role in intercellular communications.

Supplier: Bachem Americas

MEN10376 is a potent antagonist with high affinity and selectivity for the NK-2 receptor in vitro and in vivo.

Supplier: Bachem Americas

This NPY analog is a highly potent and selective ligand for Y₁ receptors in different cell lines and tissues. It has therefore been used to detect the NPY/PYY receptor subtype distribution, e.g., in rat brain. The peptide is also active in vivo, showing an even higher potency than NPY in increasing blood pressure in anesthetized rats.

Supplier: Bachem Americas

Trypanothione was purified from the insect trypanosomatid Crithidia fasciculata and identified as a covalently linked adduct of glutathione and spermidine. It is utilized as a substrate by trypanothione reductase, a unique enzyme found in trypanosomes and leishmanias (Km = 51 µM).
Sequence: N1,N8-Bis(glutathionyl)-spermidine disulfide
CAS Number: 96304-42-6
Molecular Formula: C27H47N9O10S2
Molecular Weight: 721.86

Supplier: Bachem Americas

GRGDTP prevents cell attachment of fibronectin.