Recombinant Murine Noggin

Mouse Recombinant Noggin (from E. coli)

# de catalogue 10773-430

Fournisseur: Peprotech

Numéro CAS:

Certificats

Mouse Recombinant Noggin (from E. coli)

# de catalogue 10773-430

Fournisseur: Peprotech

Numéro CAS:

Certificats

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Spécifications

Gene ID:
18121 P97466
Protease-free:
Y
Protein Function:
Cytokines and Growth Factors
Protein/peptide type:
Recombinant
Source:
E. coli
Species:
Mouse
Conjugation:
Unconjugated
Size:
100 μg
Storage conditions:
Store at –20 °C prior to reconstitution.
Endotoxin content:
>0.1 ng/μg
Biological activity:
Biological Activity tests can vary. Please refer to the Product CoA for information.
Form:
Lyophilized
Reconstitution instructions:
Reconstitution instructions can vary. Please refer to the product CoA for info.
Protein/peptide name:
Noggin
Purity:
0.98
Molecular weight:
46.4 kDa
Sequence:
MQHYLHIRPA PSDNLPLVDL IEHPDPIFDP KEKDLNETLL RSLLGGHYDP GFMATSPPED RPGGGGGPAG GAEDLAELDQ LLRQRPSGAM PSEIKGLEFS EGLAQGKKQR LSKKLRRKLQ MWLWSQTFCP VLYAWNDLGS RFWPRYVKVG SCFSKRSCSV PEGMVCKPSK SVHLTVLRWR CQRRGGQRCG WIPIQYPIIS ECKCSC
Endotoxin level:
Low
Formulation:
Formulation can vary. Please refer to product CoA for information.
Shipping temperature:
Ambient
Cat. no.:
10773-430
Origin:
USA
Supplier No.:
250-38-100UG

Spécifications

A propos de cet article

Noggin belongs to a group of diffusible proteins that bind to ligands of the TGF-β family, and regulate their activity by inhibiting their access to signaling receptors. Noggin was originally identified as a BMP-4 antagonist whose action was critical for proper formation of the head and other dorsal structures. Consequently, noggin has been shown to modulate the activities of other BMPs including BMP-2,-7,-13, and -14. Targeted deletion of noggin in mice results in prenatal death, and a recessive phenotype displaying a severely malformed skeletal system. Conversely, transgenic mice over-expressing noggin in mature osteoblasts display impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis. Recombinant Murine Noggin is a 46.4 kDa disulfide-linked homodimer consisting of two 206 amino acid polypeptide chains.

Ordering information: For research use only. Not for use in diagnostic or therapeutic procedures.

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