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Spécifications
- Antibody type:Primary
- Antigen name:Insulin-like Growth Factor 1 Receptor
- Clonality:Monoclonal
- Clone:alphaIR3
- Gene ID:3480
- Host:Mouse
- Isotype:IgG1
- Neutralisation:Yes
- Reactivity:Human
- Antigen symbol:IGF1R
- Conjugation:Unconjugated
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- ImmunoPrecipitation:Yes
- Size:50 μg
- Antigen synonyms:MGC18216|JTK13|CD221|IGFIR|MGC142170|IGF1R|MGC142172
- Storage buffer:0.05 M sodium phosphate buffer, 0.2% gelatin, and =0.1% sodium azide.
- Storage temperature:Keep as concentrated solution, aliquot and store at 4°C. Do not freeze.
- Concentration:0.1 mg/ml
- Immunogen:Immunogen used was partially purified receptor from human placenta.
- Tested applications:ICC/IF, IP, Neut
- Purification:Affinity purified with antigen
- Cat. no.:89351-276
- Supplier No.:GTX16890
Spécifications
A propos de cet article
There are two kinds of IGF receptors based on their relative affinities for IGFI versus IGFII. The IGFI receptor prefers IGFI over IGFII and weakly binds insulin. IGFI receptor is a disulfide-linked heterotetrameric transmembrane protein consisting of two alpha (130 kD) and two beta (95 kD) subunits. Both the alpha and beta subunits are encoded within a single receptor precursor cDNA. The IGFI receptor is therefore similar in structure to the insulin receptor. The proreceptor polypeptide is proteolytically cleaved and disulfide-linked to yield the mature heterotetrameric receptor. The alpha subunit of the IGFI receptor is extracellular while the beta subunit has an extracellular domain, a transmembrane domain and a cytoplasmic tyrosine kinase domain. The IGFI receptor is highly expressed in all cell types and tissues. Essentially all of the biological activities of IGFI and II have been shown to be mediated via the IGFI receptor.
For IF: Use at a concentration of 1 - 5 ?g/ml. For IP: Use at an assay dependent dilution. For Neut: Use at a concentration of 1 ?g/ml. Not suitable for use in IHC-P or WB. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher.
Type: Primary
Antigen: IGF1R
Clonality: Monoclonal
Clone: alphaIR3
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human