To order chemicals, medical devices, or other restricted products please provide ID that includes your business name & shipping address via email [email protected] or fax 484.881.5997 referencing your VWR account number. Acceptable forms of ID are:
- • State issued document with your organization's Federal Tax ID Number
- • State issued document with your organization's Resale Tax ID Number
- • City or County issued Business License
- • State Department of Health Services License
- • Any other ID issued by the State that includes the business name & address
* ATTN: California Customers may require additional documentation as part of the CA Health & Safety Code. Products that fall under this regulation will be placed on a mandatory 21-day hold after documentation is received. VWR will not lift restrictions for residential shipping addresses.
Spécifications
- Antibody type:Primary
- Antigen name:Adipocyte Plasma Membrane Associated Protein
- Clonality:Monoclonal
- Clone:Ne.Na
- Gene ID:9370
- Host:Mouse
- Isotype:IgG1
- Reactivity:Human
- Antigen symbol:APMAP
- Conjugation:Unconjugated
- ELISA:Yes
- ImmunoPrecipitation:Yes
- Size:50 μg
- Western blot:Yes
- Antigen synonyms:a|Adipose most abundant gene transcript 1|30 kDa adipocyte complement-related protein|Adipocyte|ACRP30|C1q and collagen domain-containing protein
- Storage buffer:Phosphate-buffered saline containing 0.02% sodium azide
- Storage temperature:Keep as concentrated solution. Store at 4 °C short term. For extended storage aliquot and store at –20 °C or below. Avoid freeze-thaw cycles.
- Concentration:1 mg/ml
- Immunogen:Recombinant human ACRP30 headless (tail adiponectin) protein.
- Tested applications:ELISA, IP, WB
- Purification:>95% by SDS-PAGE
- Cat. no.:89360-148
- Supplier No.:GTX16086
Spécifications
A propos de cet article
Adipose cells produce and secrete numerous physiologically important proteins, such as lipoprotein lipase, leptin, and adipocyte complement related protein of 30 kDa (Acrp30). Acrp30 is a circulating protein that is secreted exclusively by differentiated adipocytes. During adipocyte differentiation, mRNA levels of Acrp30 have been shown to be induced over 100-fold. Studies indicate that Acrp30 enhances the ability of sub-physiological levels of insulin to suppress glucose production, thus linking adipose tissue to whole body glucose regulation. Acrp30 function appears to be regulated by phosphatidylinositol 3 kinase (PI3K) since Acrp30 secretion is blocked by pharmacologic inhibitors of this kinase. mRNA levels of Acrp30 have been shown to be significantly reduced in adipose tissue of obese patients with Type 2 diabetes relative to control subjects. Structural similarities to TNF alpha suggests that Acrp30 may play a role in pathogenesis of insulin resistance in Type 2 diabetes. Because Acrp30 is down-regulated in various forms of obesity and its structural similarity to TNF alpha, it is currently being investigated as an important regulator of whole body energy homeostasis.
ELISA: Use at an assay dependent dilution. IP: Use at an assay dependent dilution. WB: Use at a concentration of 1 ?g/ml. Predicted molecular weight: 29 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Type: Primary
Antigen: APMAP
Clonality: Monoclonal
Clone: Ne.Na
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human