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Spécifications
- Antibody type:Primary
- Antigen name:Fatty Acid Synthase
- Clonality:Polyclonal
- Gene ID:14102
- Host:Rabbit
- Isotype:IgG
- Reactivity:Bovine
- Antigen symbol:FAS
- Conjugation:Unconjugated
- Flow cytometry:Yes
- ImmunoChemistry:Yes
- Size:100 μg
- Western blot:Yes
- Antigen synonyms:FASTM|APO-1|ALPS1A|TNFRSF6|CD95|APT1|FAS1
- Storage buffer:Preservative: 0.09% Sodium Azide; Constituents: PBS. pH 7.2
- Storage temperature:Keep as concentrated solution. Store at 4 °C short term. For extended storage aliquot and store at –20 °C or below. Avoid freeze-thaw cycles.
- Concentration:1 mg/ml
- Immunogen:Synthetic peptide: ESLKLRRRVHETDKNC conjugated to KLH, corresponding to amino acids 29-44 of Mouse CD95 .
- Tested applications:Fluorescence-Activated Cell Sorting
- Purification:Immunogen affinity purified
- Cat. no.:89359-750
- Supplier No.:GTX13550
Spécifications
A propos de cet article
CD95, also known as FAS or APO-1, is a 36 kDa cell surface type I- membrane glycoprotein with an apparent molecular weight of 44 kDa on SDS-PAGE. CD95 is a member of the TNF receptor family, which includes TNFR-1, TNFR-2, CD27, CD30 and CD40. Binding of CD95 Ligand to CD95 or crosslinking of CD95 by anti-CD95 monoclonal antibodies leads to apoptosis of CD95 expressing cells. CD95 belongs to a subgroup of family members that have a death domain (DD) which contains 70 amino acids near the carboxyl-terminal region of the molecule. The binding of adaptor molecules to this DD is responsible for transmitting the death signal for apoptosis. Stimulation of CD95 results in aggregation of its DD, leading to the recruitment of FADD and caspase-8 that together with the receptor form the death-inducing signaling complex (DISC).
Recommended Starting Dilutions:FACS: Use at an assay dependent dilution.WB: Use at a dilution of 1:1000.IHC: Use at a dilution of 1:50.Not tested in other applications. Optimal dilution / concentration should be determined by the end user.
Type: Primary
Antigen: Fas
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Dog, Rat