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Spécifications
- Antibody type:Primary
- Antigen name:Alpha-Methylacyl-Coa Racemase
- Clonality:Polyclonal
- Gene ID:23600
- Host:Rabbit
- Isotype:IgG
- Reactivity:Human
- Antigen symbol:AMCR
- Conjugation:Unconjugated
- ImmunoChemistry:Yes
- Size:100 μg
- Western blot:Yes
- Antigen synonyms:AMACRD|RM|RACE|CBAS4
- Storage buffer:Preservative: NoneConstituents: BSA
- Storage temperature:Keep as concentrated solution. Store at 4 °C short term. For extended storage aliquot and store at –20 °C or below. Avoid freeze-thaw cycles.
- Concentration:0.75 mg/ml
- Immunogen:Synthetic peptide: TDACVTPVLT FEEWHHD(C), corresponding to C Terminal amino acids 290-307 of Human AMCR, the peptide was modified post-synthesis.
- Tested applications:Immunomicroscopy
- Purification:Immunogen affinity purified
- Cat. no.:89367-454
- Supplier No.:GTX15894
Spécifications
A propos de cet article
Alpha-methyacyl-CoA racemase (AMCR), is an enzyme invloved in beta oxidation of branched chain fatty acids and bile salt intermediates, and has recently been identified as a neomarker for prostate cancer, where it is over expressed. Several different isoforms have been reported that are produced either by extensinve alternatve splicing of 5 exons or by use of alternate initiation codons. At least 2 different transcripts, each derived from the 5 exons, have been reported, AMCR I and AMCR II. AMCR I is the most abundant form and enclodes for a 382 amino acid protein (42kDa). The other isoform AMCR II exhibits significnat homolgy to fumerate hydratase and encoes a 288 amino acid protein (32 kDa). Several other variants of IA and IIA isoforms are charcterized recently. The variants lack exon 3 and are designated as IB and IIB. In prostate tumor tissues that over express AMCR, both the A and B forms are over-expressed.
IHC: Use at a dilution of 1/100. IM: Use at an assay dependent dilution. WB: Use at a dilution of 1/500. Predicted molecular weight: 42 kDa corresponding to variant AMCR I. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Type: Primary
Antigen: AMCR
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human