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A competitive assay for used for quantification of CysLT.
- Detect all CysLTs (LTC4, LTD4, and LTE4) in urine and other sample matrices
- Assay 24 samples in triplicate or 36 samples in duplicate
- Measure CysLT levels down to 40.5 pg/mL
- Incubation: 18 hours | Development: 90 – 120 minutes | Read: Colorimetric at 405 – 420 nm
Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid via the 5-lipoxygenase (5-LO) pathway in leukocytes. LTC4, LTD4, and LTE4 are collectively referred to as cysteinyl leukotrienes (CysLTs). LTC4 and LTD4 are potent mediators of asthma and hypersensitivity. They induce bronchoconstriction, increase microvascular permeability, and are vasoconstrictors of coronary arteries. The biological activity of LTE4 is much lower in most systems studied, but its presence reflects the prior existence of LTC4 and LTD4. Cayman’s CysLT ELISA Kit is a competitive assay based on a proprietary high-affinity monoclonal antibody that can be used for quantification of CysLT in urine and other sample matrices. The assay has a range from 8.6 – 2500 pg/mL and a sensitivity (80% B/B0) of approximately 40.5 pg/mL.
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