A propos de cet article
Laminins are large hetero-trimeric, non-collagenous glycoproteins composed of α, β, and γ chains. This MAb reacts with laminin B2/1 chain of ~210 kDa and does not cross-react with other basement membrane components or fibronectin. Its specificity was established by immunoprecipitation and immunofluorescence of human skeletal muscle and kidney with laminin chain-specific MAbs. Epithelial sheets in vivo are separated from the mesenchymal elements of the stroma by a thin layer of a specialized type of extracellular matrix termed the basement membrane (BM). This structure consists of individual components, some of which are ubiquitous in BMs and some are not. The ubiquitous ones comprise laminin (LN), entactin/nidogen (EN), collagen type IV (CIV), and large heparan sulfate proteoglycan (HSPG), which interact specifically with each other to form a continuous and regular BM. Alterations of BM integrity, from local discontinuities up to complete loss, are described in many types of human and animal epithelial neoplasms. This MAb stains uniformly all human and murine basement membranes.
CF® dyes are Biotium's next-generation fluorescent dyes. CF®543 is an orange fluorescent dye (Ex/Em 541/560 nm) designed for the 543 nm laser line. It yields the brightest conjugates among spectrally similar dyes.
Type: Primary
Antigen: LAMC1
Clonality: Monoclonal
Clone: Clone A5
Conjugation: CF543
Epitope:
Host: Rat
Isotype: IgG2a, kappa
Reactivity: Human, Mouse
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Spécifications
- Catalog No:
- 75981-324
- 75981-326
- Antigen name:
- Laminin
- Laminin
- Antibody type:
- Primary
- Primary
- Clonality:
- Monoclonal
- Monoclonal
- Clone:
- A5
- A5
- Host:
- Rat
- Rat
- Gene ID:
- Unigene ID: 609663
- Unigene ID: 609663
- Isotype:
- IgG2a kappa
- IgG2a kappa