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Specifications
- Antibody type:Primary
- Antigen name:Cytotoxic T-Lymphocyte Antigen 4
- Antigen symbol:CTLA4
- Clonality:Monoclonal
- Clone:BNI3
- Conjugation:APC (Allophycocyanin)
- Flow cytometry:Yes
- Host:Mouse
- Isotype:IgG2a kappa
- Reactivity:Human
- Size:25 tests
- Antigen synonyms:Cytotoxic T-Lymphocyte Antigen 4|CTLA4|BNI3|CD152
- Form:liquid
- Cat. no.:75842-236
- Supplier No.:14611-80-25
Specifications
About this item
The BNI3 monoclonal antibody specifically reacts with human CD152, the Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4). CTLA-4 is expressed on activated CD28+ T cells, and binds the B7 family members B7-1 (CD80) and B7-2 (CD86). The structure of CTLA-4 is similar to the structure of CD28, but the two molecules seem to have opposite roles on the T lymphocytes. CTLA-4 inhibits the progression of T cell activation, while CD28 stimulates it. This result explains the stimulating role that the immobilization of BNI3 plays on the T lymphocytes proliferation induced by CD28.
Type: Primary
Antigen: CTLA4
Clonality: Monoclonal
Clone: BNI3
Conjugation: APC (Allophycocyanin)
Epitope:
Host: Mouse
Isotype: IgG2a, kappa
Reactivity: Human