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Spécifications
- Description:Glyoxalase Assay Kit
- Size:100 assays
- Method:OD240 nm
- Sample:Enzyme preparations or biological samples
- Processing time:30 minutes
- Cat. no.:75877-976
- Supplier No.:DGLO-100
Spécifications
A propos de cet article
For quantitative determination of glyoxalase activity.
- Linear detection range 0.4 to 80 U/L
- Can be readily automated for processing thousands of samples per day
Glyoxalase I (GLO-1), a lactoylglutathione lyase also known as methylglyoxalase, aldoketomutase, ketone-aldehyde mutase, and (R)-S-lactoylglutathione methylglyoxal-lyase, is an enzyme that catalyzes the isomerization of hemithioacetal adducts which are formed in spontaneous reactions between glutathionyl groups and aldehydes
Glyoxalase I is a target for the development of pharmaceuticals against bacteria, protozoans and human cancer. Simple, direct and automation-ready. Procedures for measuring GLO-1 activity in biological samples are highly desirable in research and drug discovery. BioAssay Systems’ Glyoxalase I assay kit provides a sensitive and convenient method for GLO-1 activity determination. The method involves monitoring the increase in the product of the GLO-1 reaction, S-lactoylglutathione, by measuring the change in absorbance at 240 nm.
The primary physiological function of glyoxalase I is the detoxification of methylglyoxal, a reactive 2-oxoaldehyde that is cytostatic at low concentrations and cytotoxic at millimolar concentrations.