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Spécifications
- Antibody type:Primary
- Antigen name:CD28 molecule
- Clonality:Monoclonal
- Clone:CD28.6
- Gene ID:940
- Host:Mouse
- Isotype:IgG2a kappa
- Reactivity:Human
- Antigen symbol:T44
- Flow cytometry:Yes
- Size:100 µg
- Western blot:Yes
- Storage temperature:2 to 8 °C protected from light
- Cat. no.:75875-730
- Supplier No.:40-0288-U100
Spécifications
A propos de cet article
The CD28.6 antibody reacts with human CD28, a 44 kDa type I surface glycoprotein which acts as a co-stimulatory receptor in support of the T cell receptor (TCR). CD28 exists as a homodimer with specificity for two known ligands, known as B7-1 (CD80) and B7-2 (CD86), which are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between the B7 ligands and CD28 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response. The CD28.6 antibody is reported to have neutralizing activity and is also useful for western blotting.
Type: Primary
Antigen: CD28
Clonality: Monoclonal
Clone: CD28.6
Conjugation:
Epitope:
Host: Mouse
Isotype: IgG2a, kappa
Reactivity: Human