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Spécifications
- Enzyme type:Recombinant
- Source:E. coli
- Species:Human
- Size:0.05 mg
- Storage conditions:Store at −20 °C, stable for 6 months after receipt. Please minimize freeze−thaw cycles.
- Endotoxin content:<0.1 ng/ug (1 IEU/ug) as determined by LAL test.
- Enzyme name:B Lymphocyte Kinase
- Enzyme synonyms:Tyrosine-Protein Kinase Blk, B Lymphocyte Kinase, p55-Blk, BLK
- Purity:>95% as determined by reducing SDS-PAGE
- Molecular weight:58.7 kD
- Sequence:Gly2-Pro505
- Formulation:Supplied as a 0.2 µm filtered solution of 20 mM Tris, 500 mM NaCl, 1 mM DTT, pH 7.4. Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
- Tested applications:Bioassay
- Cat. no.:75790-808
- Supplier No.:92-107
Spécifications
A propos de cet article
Tyrosine-Protein Kinase Blk (BLK) contains one protein kinase domain, one SH2 domain and one SH3 domain
This recombinant protein can be used for biological assays. For research use only.
Fusion-Tag: C-6 His tag
BLK is a non-receptor tyrosine kinase, which is involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulines and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor. Defects in BLK are a cause of maturity-onset diabetes of the young type 11 (MODY11).