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Spécifications
- Protein/peptide type:Recombinant
- Source:Cells
- Species:Human
- Size:0.05 mg
- Tag sequence:C-Fc-6 His tag
- Storage conditions:Lyophilized protein should be stored at −20 °C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 °C for 2-7 days. Aliquots of reconstituted samples are stable at −20 °C for 3 months.
- Endotoxin content:<0.1 ng/ug (1 IEU/ug) as determined by LAL test.
- Protein synonyms:Myeloid Cell Surface Antigen CD33|Sialic Acid-Binding Ig-like Lectin 3|gp67|SIGLEC3|CD33|Siglec-3
- Protein/peptide name:Siglec-3
- Purity:> 95% as determined by reducing SDS-PAGE
- Molecular weight:55.01 kD
- Sequence:Asp18-His259
- Formulation:Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, 2mM EDTA, pH 7.2. Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the Lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
- Tested applications:Bioassay
- Cat. no.:75789-478
- Supplier No.:91-401
Spécifications
A propos de cet article
CD33 is a type I Lectin belonging to the Ig superfamily. CD33 contains an N terminal Ig like V type domain, which mediates sialic acid binding, followed by one Ig like C2 type domain, a transmembrane region and a cytoplasmic tail containing two conserved immunoreceptor tyrosine based inhibition motifs (ITIMs). Eleven human Siglecs have been characterized. Siglecs 5 to 11 share a high degree of sequence similarity with CD33/Siglec3 both in their extracellular and intracellular regions. They are collectively referred to as CD33 related Siglecs. CD33 related Siglecs have differential expression pattern within the hematopoietic system. They are involved in the regulation of cellular activation within the immune system. Siglec 3 expression is restricted to cells of myelomonocytic lineage. Siglec3 recruits SHP1 and SHP2 to its ITIMs upon phosphorylation.
- Fusion-Tag: C-Fc-6 His tag
This recombinant protein can be used for biological assays. For research use only.