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Spécifications
- Antibody type:Primary
- Antigen name:Small Ubiquitin-Like Modifier 2 and 3
- Clonality:Polyclonal
- Host:Rabbit
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Antigen symbol:SUMO2/3
- Conjugation:Cy5.5®
- ImmunoChemistry:Yes
- Size:100 µL
- Cross adsorption:No
- Form:liquid
- Antigen synonyms:Suppressor of m two 3 homolog 2|SMT3 A|Suppressor of m two 3 homolog 3|SUMO3_HUMAN.|SMT3 B|OTTHUMP00000115275|SMT3 suppressor of m two 3 homolog 2 S. cerevisiae|Small ubiquitin like modier protein 3|SMT3 homolog 1|Sumo3|Small ubiquitin related modier 3|Sumo2|SMT3 H1|SMT3H1|OTTHUMP00000115276|HSMT3|SMT3 homolog 2|SUMO2_HUMAN|MGC117191|Ubiquitin like protein SMT3B|Small ubiquitin related modier 2|OTTHUMP00000115277|Sumo 2|Sentrin 2|SMT3 homolog|SMT3 suppressor of m two 3 homolog 3|SMT3 H2|Sumo 3|SMT3B|SMT3A|SMT3 suppressor of m two 3 homolog 1|Ubiquitin like protein SMT3A|SMT3 suppressor of m two 3 homolog 3 S. cerevisiae|SMT3 suppressor of m two 3 homolog 2|SMT3H2|Small ubiquitin like modier 2
- Storage buffer:Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
- Storage temperature:Store at –20 °C for 12 months
- Concentration:1 μg/μl
- Shipping temperature:4°C
- Purification:Purified by Protein A
- Cat. no.:10462-864
- Supplier No.:BS-7338R-CY5.5
Spécifications
A propos de cet article
The small ubiquitin-related modifier (SUMO) proteins, which include SUMO-1, SUMO-2 and SUMO-3, belong to the ubiquitin-like protein family. Like ubiquitin, the SUMO proteins are synthesized as precursor proteins that undergo processing before conjugation to target proteins. Also, both utilize the E1, E2, and E3 cascade enzymes for conjugation. However, SUMO and ubiquitin differ with respect to targeting. Ubiquitination predominantly targets proteins for degradation, whereas sumoylation targets proteins to a variety of cellular processing, including nuclear transport, transcriptional regulation, apoptosis and protein stability. The unconjugated SUMO-1, SUMO-2 and SUMO-3 proteins localize to the nuclear membrane, nuclear bodies and cytoplasm, respectively. SUMO-1 utilizes Ubc9 for conjugation to several target proteins, which include IkBa, MDM2, p53, PML and Ran GAP1. SUMO-2 and SUMO-3 contribute to a greater percentage of protein modification than does SUMO-1, and unlike SUMO-1, they can form polymeric chains. In addition, SUMO-3 regulates b-Amyloid generation and may be critical in the onset or progression of Alzheimer’s disease.
Recommended Dilutions: IF(IHC-P): 1:50-200
Type: Primary
Antigen: SUMO 2/3
Clonality: Polyclonal
Clone:
Conjugation: Cy5.5®
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat