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Spécifications
- Antibody type:Primary
- Antigen name:Hypoxia inducible Factor 3 alpha Subunit
- Clonality:Polyclonal
- Gene ID:64344
- Host:Rabbit
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Antigen symbol:HIF3A
- Conjugation:Cy3®
- ImmunoChemistry:Yes
- Size:100 µL
- Cross adsorption:No
- Form:liquid
- Antigen synonyms:PASD7|HIF3A|Class E basic helix-loop-helix protein 17|Member of PAS protein 7|Hypoxia-inducible factor 3-alpha|HIF-3-alpha|IPAS|BHLHE17|bHLHe17|HIF3-alpha-1|Basic-helix-loop-helix-PAS protein MOP7|HIF3-alpha|PAS domain-containing protein 7|MOP7|Inhibitory PAS domain protein
- Storage buffer:Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
- Storage temperature:Store at 4°C for 12 months
- Concentration:1 μg/μl
- Shipping temperature:4°C
- Immunogen:161-200/669
- Purification:Purified by Protein A
- Cat. no.:10425-890
- Supplier No.:BS-5898R-CY3
Spécifications
A propos de cet article
Involved in adaptive response to hypoxia. Suppresses hypoxia-inducible expression of HIF1A and EPAS1. Binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters. The complex HIF3A-ARNT activates the transcription of reporter genes driven by HRE. Isoform 4 has a dominant-negative function of inactivating HIF1A-mediated transcription. Isoform 4 attenuates the binding of HIF1A to hypoxia-responsive elements (HRE), thus inhibiting HRE-driven transcription. Hypoxia induces down-regulation of isoform 4, leading to activation of HIF1A in hypoxia. Conversely, upon restoring normoxia, the expression of isoform 4 increases and thereby secure an inhibition of HIF1A activity. Isoform 4 may be a negative regulator of hypoxia-inducible gene expression in the kidney and may be involved in renal tumorigenesis. Functions as an inhibitor of angiogenesis in the cornea (By similarity).
Recommended Dilutions: IF(IHC-P): 1:50-200
Type: Primary
Antigen: HIF3A
Clonality: Polyclonal
Clone:
Conjugation: Cy3®
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat