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Spécifications
- Antibody type:Primary
- Antigen name:SMAD Family member 1 And 5
- Clonality:Polyclonal
- Gene ID:4086, 4090
- Host:Rabbit
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Antigen symbol:SMAD1 + SMAD5
- Conjugation:Alexa Fluor® 647
- ImmunoChemistry:Yes
- Size:100 µL
- Cross adsorption:No
- Form:liquid
- Antigen synonyms:mothers against DPP homolog 1|BSP-1|Mad-related protein 1|SMAD5|mothers against decapentaplegic homolog 1|SMAD1|DWFC|MADH5|TGF-beta signaling protein 1|MAD|JV5-1|transforming growth factor-beta signaling protein 1|MAD homolog 1|hSMAD1
- Modification:phospho-Ser463/Ser465
- Storage buffer:Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
- Storage temperature:Store at 4°C for 12 months
- Concentration:1 μg/μl
- Shipping temperature:4°C
- Immunogen:440-465/465
- Purification:Purified by Protein A
- Cat. no.:10373-118
- Supplier No.:BS-3418R-A647
Spécifications
A propos de cet article
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq].
Recommended Dilutions: IF(IHC-P): 1:50-200
Type: Primary
Antigen: Smad1/5
Clonality: Polyclonal
Clone:
Conjugation: Alexa Fluor® 647
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat