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Spécifications
- Antibody type:Primary
- Antigen name:Insulin Receptor Substrate 1
- Clonality:Polyclonal
- Gene ID:3667
- Host:Rabbit
- Isotype:IgG
- Reactivity:Human
- Antigen symbol:IRS1
- Conjugation:Alexa Fluor® 647
- ImmunoChemistry:Yes
- Size:100 µL
- Cross adsorption:No
- Form:liquid
- Antigen synonyms:IRS 1|HIRS 1|IRS1|HIRS1|IRS-1|IRS1Tyr1229|Insulin Receptor Substrate 1|p-IRS1
- Modification:phospho-Tyr1229
- Storage buffer:Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
- Storage temperature:Store at 4°C for 12 months
- Concentration:1 μg/μl
- Shipping temperature:4°C
- Purification:Purified by Protein A
- Cat. no.:10354-176
- Supplier No.:BS-3203R-A647
Spécifications
A propos de cet article
Insulin receptor substrates (IRS) are responsible for several insulin related activities, such as glucose homeostasis, cell growth, cell transformation, apoptosis and insulin signal transduction. Serine/threonine phosphorylation of IRS1 has been demonstrated to be a negative regulator of insulin signaling and is responsible for its degradation, although IRS1 degradation pathways are not well understood. IRS1 has also been shown to be constitutively activated in cancers such as breast cancer, Wilm's tumors, and adrenal cortical carcinomas, thus making IRS1 phosphorylation and subsequent degradation an attractive therapeutic target. To date there have been four subtypes identified: IRS1, 2, 3 and 4, with IRS1 being widely expressed.
Recommended Dilutions: IF(IHC-P): 1:50-200
Type: Primary
Antigen: IRS1
Clonality: Polyclonal
Clone:
Conjugation: Alexa Fluor® 647
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human