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Spécifications
- Antibody type:Primary
- Antigen name:B-cell linker
- Clonality:Polyclonal
- Gene ID:29760
- Host:Rabbit
- Isotype:IgG
- Reactivity:Human
- Antigen symbol:BLNK
- Conjugation:Unconjugated
- ImmunoChemistry:Yes
- Size:100 µL
- Western blot:Yes
- Cross adsorption:No
- Form:liquid
- Antigen synonyms:Src homology 2 domain-containing leukocyte protein of 65 kDa|B-cell adapter containing a Src homology 2 domain protein|B cell adaptor containing SH2 domain|B cell linker protein|cytoplasmic adapter protein|SLP-65|B-cell activation|LY57|AGM4|B-cell adapter containing a SH2 domain protein|BLNK-S|bca|B-cell linker protein|SLP65|BASH|Src homology [SH2] domain-containing leukocyte protein of 65 kD
- Modification:phospho-Tyr96
- Storage buffer:Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.
- Storage temperature:Store at –20 °C for 12 months
- Concentration:1 μg/μl
- Shipping temperature:4°C
- Immunogen:70-120/456
- Purification:Purified by Protein A
- Cat. no.:10350-584
- Supplier No.:BS-3054R
Spécifications
A propos de cet article
Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis.
Recommended Dilutions: Western Blot: 1:100-1000; IHC-P: 1:100-500; IF(IHC-P): 1:50-200
Type: Primary
Antigen: BLNK
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human