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Spécifications
- Antibody type:Primary
- Antigen name:Caspase 8
- Clonality:Polyclonal
- Gene ID:12370
- Host:Rabbit
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Antigen symbol:CASP8
- Conjugation:Cy5.5®
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Size:100 µL
- Cross adsorption:No
- Form:liquid
- Antigen synonyms:FLICE|caspase 8|MACH-beta-1/2/3/4 protein|FADD-homologous ICE/CED-3-like protease|MCH5|apoptotic protease Mch-5|FADD-like ICE|MACH-alpha-1/2/3 protein|CAP4|ALPS2B|apoptotic cysteine protease|Casp-8|MORT1-associated ced-3 homolog|caspase-8|apoptosis-related cysteine protease|ICE-like apoptotic protease 5|MACH
- Storage buffer:Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
- Storage temperature:Store at 4°C for 12 months
- Concentration:1 μg/μl
- Shipping temperature:4°C
- Immunogen:430-482/482
- Purification:Purified by Protein A
- Cat. no.:10230-108
- Supplier No.:BS-0052R-CY5.5
Spécifications
A propos de cet article
Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP1. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein.
Recommended Dilutions: IF(IHC-P): 1:50-200; IF(ICC)(1:50-200
Type: Primary
Antigen: CASP8
Clonality: Polyclonal
Clone:
Conjugation: Cy5.5®
Epitope:
Host: Rabbit
Isotype: IgG1
Reactivity: Human, Mouse, Rat