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Spécifications
- Antibody type:Primary
- Antigen name:Apoptosis-Inducing Factor, Mitochondrion-Associated, 1
- Clonality:Polyclonal
- Gene ID:9131
- Host:Rabbit
- Isotype:IgG
- Reactivity:Pig,Human,Rat,Mouse
- Antigen symbol:AIFM1
- Conjugation:Cy5.5®
- ImmunoChemistry:Yes
- Size:100 µL
- Cross adsorption:No
- Form:liquid
- Antigen synonyms:COWCK|NADMR|AIF|NAMSD|CMT2D|COXPD6|PDCD8|CMTX4
- Storage buffer:Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
- Storage temperature:Store at 4°C for 12 months
- Concentration:1 μg/μl
- Shipping temperature:4°C
- Immunogen:130-180/613
- Purification:Purified by Protein A
- Cat. no.:10229-612
- Supplier No.:BS-0037R-CY5.5
Spécifications
A propos de cet article
Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast, functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner.
Recommended Dilutions: IF(IHC-P): 1:50-200
Type: Primary
Antigen: AIFM1
Clonality: Polyclonal
Clone:
Conjugation: Cy5.5®
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat, Pig