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Spécifications
- Antibody type:Primary
- Antigen name:Presenilin 1
- Clonality:Polyclonal
- Gene ID:29192
- Host:Mouse
- Isotype:IgG
- Reactivity:Rabbit,Human,Rat
- Antigen symbol:PSEN1
- Conjugation:Alexa Fluor® 555
- ImmunoChemistry:Yes
- Size:100 µL
- Cross adsorption:No
- Form:liquid
- Antigen synonyms:FAD|Alzheimer Disease 3|Homo Sapiens Clone CC44 Senilin 1|Senilin 1|PS1|PSNL1|AD3|S182 Protein
- Storage buffer:Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
- Storage temperature:Store at 4°C for 12 months
- Concentration:1 μg/μl
- Shipping temperature:4°C
- Immunogen:1-50/467
- Purification:Purified by Protein A
- Cat. no.:10229-474
- Supplier No.:BS-0024M-A555
Spécifications
A propos de cet article
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis (By similarity).
Recommended Dilutions: IF(IHC-P): 1:50-200
Type: Primary
Antigen: PSEN1
Clonality: Polyclonal
Clone:
Conjugation: Alexa Fluor® 555
Epitope:
Host: Mouse
Isotype: IgG
Reactivity: Human, Rat, Rabbit