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Spécifications
- Antibody type:Primary
- Antigen name:Mitogen-Activated Protein Kinase 1
- Clonality:Polyclonal
- Gene ID:26413
- Host:Rabbit
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Antigen symbol:MAPK1
- Conjugation:Alexa Fluor® 555
- ImmunoChemistry:Yes
- Size:100 µL
- Cross adsorption:No
- Form:liquid
- Antigen synonyms:P42MAPK|PRKM2|ERK2|PRKM1|MAPK2|ERK|ERT1|p38|p41mapk|ERK-2|p40|p42-MAPK|p41
- Storage buffer:Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
- Storage temperature:Store at 4°C for 12 months
- Concentration:1 μg/μl
- Shipping temperature:4°C
- Immunogen:330-358/358
- Purification:Purified by Protein A
- Cat. no.:10229-234
- Supplier No.:BS-0022R-A555
Spécifications
A propos de cet article
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis.
Recommended Dilutions: IF(IHC-P): 1:50-200
Type: Primary
Antigen: MAPK1
Clonality: Polyclonal
Clone:
Conjugation: Alexa Fluor® 555
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat