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Fibroblast growth factor 22 (FGF22) is a mediator of synaptogenesis in the adult nervous system and functions to regulate synapse formation and maturation. FGF22 is expressed in the inner hair cell and functions to maintain ribbon synapse number to protect functional hearing. In the hippocampus, FGF22 promotes excitatory synapse formation through binding the FGFR2b and FGFR1b receptors. FGF22 is also required for axonal circuit remodeling after spinal cord injury.
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