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Spécifications
- Antibody type:Primary
- Antigen name:Programmed cell death protein 1
- Clonality:Monoclonal
- Clone:J43.1
- Gene ID:18566
- Host:Armenian hamster
- Isotype:IgG
- Reactivity:Mouse
- Antigen symbol:PD1
- Flow cytometry:Yes
- ImmunoChemistry:Yes
- ImmunoPrecipitation:Yes
- Size:100 µg
- Antigen synonyms:PD-1|hPD-1|hPD-l|programmed cell death protein 1|CD279|protein PD-1|PD1|SLEB2
- Storage temperature:2-8°C
- Tested applications:Functional Assay
- Cat. no.:10208-432
- Supplier No.:40-9985-U100
Spécifications
A propos de cet article
The J43.1 antibody is specific for mouse CD279, also known as programmed death-1 (PD-1), a 55 kDa glycoprotein which can co-regulate T cell antigen receptor signaling and therefore modulate T cell activation. PD-1 exists in a monomeric form that is expressed by CD4- CD8- thymocytes, where it participates in the processes of clonal selection, elimination of autoreactive lymphocytes, and development of tolerance. PD-1 expression is also inducible upon activation of mature T cells, where it has been proposed to interact with the co-stimulatory receptor CD80 to limit T cell activation. Two ligands for PD-1, known as PD-L1 (B7-H1) and PD-L2 (B7-DC) are differentially expressed on T and B cells, monocytes, macrophages, NK cells or dendritic cells. PD-1 is a member of a family of receptors including CD28 and CTLA-4 (CD152), which interact with “B7” ligands to provide a balance of co-stimulatory /co-inhibitory signaling important in T cell activation, tolerance, and autoimmunity.
The J43.1 antibody may be used as a marker for PD-1 expression, and is commonly used for analysis of receptor-ligand interaction and function(s) in vitro and in vivo. Please choose the appropriate format for each application.
Type: Primary
Antigen: PD1
Clonality: Monoclonal
Clone: J43.1
Conjugation:
Epitope:
Host: Armenian Hamster
Isotype: IgG
Reactivity: Mouse