A propos de cet article
The C17.8 antibody is specific for the 40 kDa (p40) protein subunit shared by the cytokines IL-12 and IL-23. To form IL-12, p40 assembles with a separate 35 kDa protein known as p35, resulting in a 70 kDa functional cytokine. IL-12 is secreted by activated monocytes, macrophages, and dendritic cells, and has been shown to target naïve, resting CD4+ T cells to promote their proliferation and secretion of cytokines. IL-23 contains the p40 subunit in combination with a 19 kDa protein chain, p19; its primary source being activated dendritic cells and other antigen-presenting cells. IL-23 appears to target different cell types than IL-12, acting on memory CD4+ T cells to induce a strong proliferative response and contributing to the generation and expansion of Th17 cells. Like the cytokines themselves, the receptors for IL-12 and IL-23 share one subunit, as well as containing distinct cytokine-specific subunits.
As the C17.8 antibody binds to a shared subunit of both IL-12 and IL-23, it may be used as a marker for either IL-12 or IL-23 expression in dendritic cells, monocytes and macrophages, and is widely used for neutralization of activity associated with either cytokine. Please choose the appropriate format for each application.
Type: Primary
Antigen: IL12B
Clonality: Monoclonal
Clone: C17.8
Conjugation:
Epitope:
Host: Rat
Isotype: IgG2a
Reactivity: Mouse
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Spécifications
- Catalog No:
- 10051-134
- 10051-132
- Antigen name:
- Interleukin 12 Beta
- Interleukin 12 Beta
- Antibody type:
- Primary
- Primary
- Clonality:
- Monoclonal
- Monoclonal
- Clone:
- C17.8
- C17.8
- Host:
- Rat
- Rat
- Gene ID:
- 16160
- 16160
- Isotype:
- IgG2a
- IgG2a