A propos de cet article
The UC10-4F10-11 antibody is specific for mouse CD152, commonly known as CTLA-4, a 33-37 kDa protein expressed as a homodimer on the surface of activated T and B cells, and on thymocytes. CTLA-4 is structurally similar, yet functionally disparate, to the T cell co-stimulatory molecule CD28. Both CTLA-4 and CD28 interact with the co-stimulatory molecules CD80 (B7-1) and CD86 (B7-2) on antigen-presenting cells, with CTLA-4 displaying a higher avidity than CD28. While CD28 typically delivers a potent co-stimulatory signal in support of T cell activation, CTLA-4 appears to act as a negative regulator of T cell activation and may contribute to the suppressor function of Treg cells.
CTLA-4 proteins may be initially sequestered within Golgi vesicles, from which they can be rapidly transferred to and from the cell surface, a mechanism by which Treg cells can selectively impart suppressive functions. The UC10-4F10-11 antibody may be used for flow cytometric analysis of CTLA-4 expression.
Type: Primary
Antigen: CTLA4
Clonality: Monoclonal
Clone: UC10-4F10-11
Conjugation: APC (Allophycocyanin)
Epitope:
Host: Armenian Hamster
Isotype:
Reactivity:
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Spécifications
- Catalog No:
- 10050-586
- 10050-588
- Antigen name:
- Cytotoxic T-lymphocyte-Associated Protein 4
- Cytotoxic T-lymphocyte-Associated Protein 4
- Antibody type:
- Primary
- Primary
- Clonality:
- Monoclonal
- Monoclonal
- Clone:
- UC10-4F10-11
- UC10-4F10-11
- Host:
- Armenian hamster
- Armenian hamster
- Gene ID:
- 12477
- 12477
- Isotype:
- IgG
- IgG