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Spécifications
- Antibody type:Primary
- Antigen name:Cytotoxic T-lymphocyte-Associated Protein 4
- Clonality:Monoclonal
- Clone:BNI3
- Gene ID:1493
- Host:Mouse
- Isotype:IgG2a
- Neutralisation:Yes
- Reactivity:Baboon,Cynomolgus monkey,Macaque,Human
- Antigen symbol:CTLA4
- Conjugation:Unconjugated
- Flow cytometry:Yes
- ImmunoChemistry:Yes
- ImmunoPrecipitation:Yes
- Size:100 µg
- Antigen synonyms:IDDM12|GRD4|GSE|CD|CTLA-4|ALPS5|cytotoxic T-lymphocyte associated protein 4|CD152|CELIAC3
- Storage temperature:Store undiluted at 2-8°C, protect from light, do not freeze.
- Tested applications:Flow Cytometry
- Cat. no.:10051-714
- Supplier No.:70-1529-U100
Spécifications
A propos de cet article
The BNI3 antibody is specific for human CD152, commonly known as CTLA-4, a 33-37 kDa protein expressed as a homodimer on the surface of activated T and B cells, and on thymocytes. CTLA-4 is structurally similar, yet functionally disparate, to the T cell co-stimulatory molecule CD28. Both CTLA-4 and CD28 interact with the co-stimulatory molecules CD80 (B7-1) and CD86 (B7-2) on antigen-presenting cells, with CTLA-4 displaying a higher avidity than CD28. While CD28 typically delivers a potent co-stimulatory signal in support of T cell activation, CTLA-4 appears to act as a negative regulator of T cell activation and may contribute to the suppressor function of Treg cells.
CTLA-4 proteins may be initially sequestered within Golgi vesicles, from which they can be transferred to and from the cell surface, a mechanism by which Treg cells can selectively impart suppressive functions. The BNI3 antibody may be used for flow cytometric analysis of intracellular or surface CTLA-4 expression, and is also widely used for neutralization of CTLA-4 when expressed at the cell surface. The BNI3 antibody is reported to be cross-reactive with Baboon, Cynomolgus and Rhesus CTLA-4. Please choose the appropriate format for each application.
Type: Primary
Antigen: CTLA4
Clonality: Monoclonal
Clone: BNI3
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype:
Reactivity: