A propos de cet article
The 11B11 antibody binds to mouse Interleukin-4 (IL-4), a 14 kDa cytokine that is largely secreted by activated T cells of the Th2 subset, and to some degree by NKT and mast cells. This cytokine acts as a stimulatory factor for B cells, inducing their proliferation and differentiation, as well as playing a role in immunoglobulin class-switching. IL-4 may also provide autocrine stimulation for T cells, and affect the function of antigen presenting cells such as macrophages and dendritic cells. IL-4 can bind and signal via three cell surface receptor types: CD124 by itself, CD124 in combination with the common gamma chain (type I complex), or CD124 combined with CD213a1 (type II complex).
The 11B11 antibody is widely used for detection of intracellular levels of IL-4 protein by flow cytometry, as well as for analysis of soluble cytokine as measured by ELISA, and in functional assays to neutralization cytokine-receptor interactions. Please choose the appropriate format for each application.
Type: Primary
Antigen: IL4
Clonality: Monoclonal
Clone: 11B11
Conjugation: APC (Allophycocyanin)
Epitope:
Host: Rat
Isotype: IgG1
Reactivity: Mouse
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Spécifications
- Catalog No:
- 10050-660
- 10050-658
- Antigen name:
- Interleukin 4
- Interleukin 4
- Antibody type:
- Primary
- Primary
- Clonality:
- Monoclonal
- Monoclonal
- Clone:
- 11B11
- 11B11
- Host:
- Rat
- Rat
- Gene ID:
- 16189
- 16189
- Isotype:
- IgG1
- IgG1