About this item
The N418 antibody reacts with mouse CD11c, also known as integrin alpha X. This 150 kDa cell surface glycoprotein is part of a family of integrin receptors that mediate adhesion between cells (cell-cell) and components of the extracellular matrix, e.g. fibrinogen (cell-matrix). In addition, integrins are active signaling receptors which recruit leukocytes to inflammatory sites and promote cell activation. Complete, functional integrin receptors consist of distinct combinations of integrin chains which are differentially expressed. Integrin alpha X (CD11c) assembles with Integrin beta-2 (CD18) into a receptor complex known as CR4 which can bind and induce signaling through ICAMs and VCAM-1 on endothelial cells and can also facilitate removal of iC3b bearing foreign cells.
The N418 antibody is widely used as a marker for CD11c expression on dendritic cells (DC), often in parallel with markers for CD11b, for identification of developmental stages and mature subsets of this cell type. CD11c is prominently expressed on tissue macrophages, and is also detected on some types of activated T cells and intestinal intraepithelial lymphocytes (IEL).
Type: Primary
Antigen: ITGAX
Clonality: Monoclonal
Clone: N418
Conjugation: APC (Allophycocyanin)-Cy7®
Epitope:
Host: Armenian Hamster
Isotype: IgG
Reactivity: Mouse
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Specifications
- Catalog No:
- 10050-698
- 10050-696
- Antigen symbol:
- ITGAX
- ITGAX
- Antigen name:
- Integrin Alpha 10
- Integrin Alpha 10
- Antigen synonyms:
- integrin alpha-X|integrin aX|ITGAX|AI449405|CD11 antigen-like family member C|N418|Cr4|Cd11c
- integrin alpha-X|integrin aX|ITGAX|AI449405|CD11 antigen-like family member C|N418|Cr4|Cd11c
- Antibody type:
- Primary
- Primary
- Clonality:
- Monoclonal
- Monoclonal
- Conjugation:
- APC (Allophycocyanin)-Cy7®
- APC (Allophycocyanin)-Cy7®
- Clone:
- N418
- N418
- Reactivity:
- Mouse
- Mouse
- Host:
- Armenian hamster
- Armenian hamster
- Gene ID:
- 16411
- 16411
- Isotype:
- IgG
- IgG
- Flow cytometry:
- Yes
- Yes
- Neutralisation:
- Yes
- Yes
- Storage temperature:
- Store undiluted at 2-8°C, protect from light, do not freeze.
- Store undiluted at 2-8°C, protect from light, do not freeze.
- Tested applications:
- Flow Cytometry
- Flow Cytometry