A propos de cet article
The H57-597 antibody is specific for the beta chain of the mouse T cell Receptor (TCR). This cell surface protein combines with a second protein chain (alpha chain) to form the alpha-beta TCR that is expressed by NK1.1+ thymocytes, NKT cells, and the majority of peripheral T cells. A small number of T cells may express an alternative heteromer of gamma/delta protein chains, known as the g/d TCR. These receptors participate in a complex with CD3, and with the co-receptors CD4 or CD8, to recognize and respond to antigens bound to MHC molecules on antigen-presenting cells. Such interactions promote T cell receptor signaling (T cell activation) and can result in a number of cellular responses including proliferation, differentiation, production of cytokines or activation-induced cell death.
The H57-597 antibody is used as a phenotypic marker for T cells expressing the alpha-beta TCR. It is also widely used to cross-link surface TCR and thereby mimic TCR-mediated cell activation or induction of apoptosis. The antibody does not cross-react with cells expressing the g/d TCR.
Type: Primary
Antigen: TCRB
Clonality: Monoclonal
Clone: H57-597
Conjugation: violetFluor® 450
Epitope:
Host: Armenian Hamster
Isotype: IgG
Reactivity: Mouse
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Spécifications
- Catalog No:
- 10051-868
- 10051-866
- Antigen name:
- T-cell Receptor beta
- T-cell Receptor beta
- Antibody type:
- Primary
- Primary
- Clonality:
- Monoclonal
- Monoclonal
- Clone:
- H57-597
- H57-597
- Host:
- Armenian hamster
- Armenian hamster
- Gene ID:
- 21577
- 21577
- Isotype:
- IgG
- IgG