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Spécifications
- Antibody type:Primary
- Antigen name:Interleukin 2 Receptor, Alpha
- Clonality:Monoclonal
- Clone:PC61.5
- Gene ID:16184
- Host:Mouse
- Isotype:IgG2a
- Neutralisation:Yes
- Reactivity:Mouse
- Antigen symbol:IL2RA
- Conjugation:Unconjugated
- Flow cytometry:Yes
- ImmunoChemistry:Yes
- ImmunoPrecipitation:Yes
- Size:100 µg
- Antigen synonyms:TCGFR|IL2-RA|p55|IL-2R subunit alpha|IL-2 receptor subunit alpha|IL-2-RA|IL2R|TAC antigen|IDDM10|CD25
- Storage temperature:Store Undiluted at 2 to 8°C; Protect from Light; Do Not Freeze.
- Cat. no.:10051-668
- Supplier No.:70-0251-U100
Spécifications
A propos de cet article
The PC61.5 antibody is specific for mouse CD25, a 55 kDa surface protein also known as the Interleukin-2 Receptor alpha chain, or IL-2R alpha. CD25 may bind IL-2 by itself, although with low affinity and without induction of cell signaling. CD25 is also expressed within a high-affinity complex, along with the IL-2R beta chain (CD122) and the common gamma chain (CD132), to form a signaling receptor complex. Expression of CD25 varies during developmental stages of T and B cells, is induced on activated mature T and B cells, and is present on subsets of dendritic cells. CD25 signaling as part of the IL-2 receptor complex triggers T cell activation and proliferation, as well as modulating the differentiation and function of Th17 cells, T regulatory (Treg) cells, and dendritic cells.
The PC61.5 antibody is used as a marker for T cells, B cells and dendritic cell subsets. Expression of CD25, CD4 and the transcription factor Foxp3 is regarded as a phenotypic signature for Treg cells. As such, this antibody is widely used to distinguish Treg cells from naïve or conventional T cells which are CD25-. This clone has also been reported for depletion of Treg cells in vivo (use format suitable for functional assays).
Type: Primary
Antigen: IL2RA
Clonality: Monoclonal
Clone: PC61.5
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG2a
Reactivity: Mouse