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Spécifications
- Protein/peptide type:Recombinant
- Source:E. coli
- Species:Human
- Size:100 µg
- Tag sequence:HIS Tag
- Protein/peptide name:UBCH7
- Purity:>95% (SDS-PAGE)
- Concentration:0.5mg/ml
- Formulation:Liquid. In HEPES, pH 7.5, containing 150 mM NaCl and 1.0mM DTT.
- Cat. no.:89165-334
- Supplier No.:UW9080-0100
Spécifications
A propos de cet article
Produced in E. coli.
Three classes of enzymes are involved in the conjugation of ubiquitin to proteins. E1, the ubiquitin activating enzyme, activates ubiquitin through the ATP-dependent formation of a high-energy thiol ester bond between the carboxyl terminus of ubiquitin and the active-site cysteine within E1. This E1-activated ubiquitin is transferred to a cysteine residue of an E2, or ubiquitin-conjugating enzyme (UbC). E2 enzymes, either by themselves or in conjunction with E3 enzymes (ubiquitin ligases), then transfer ubiquitin to target proteins forming stable isopeptide bonds resulting in multi-ubiquitin chain formation. It is the diverse combinations of E2-E3 complexes which are thought to define substrate specificity.