To order chemicals, medical devices, or other restricted products please provide ID that includes your business name & shipping address via email [email protected] or fax 484.881.5997 referencing your VWR account number. Acceptable forms of ID are:
- • State issued document with your organization's Federal Tax ID Number
- • State issued document with your organization's Resale Tax ID Number
- • City or County issued Business License
- • State Department of Health Services License
- • Any other ID issued by the State that includes the business name & address
* ATTN: California Customers may require additional documentation as part of the CA Health & Safety Code. Products that fall under this regulation will be placed on a mandatory 21-day hold after documentation is received. VWR will not lift restrictions for residential shipping addresses.
Spécifications
- Size:25 Tests
- Storage conditions:4 °C (Long Term)
- Application:Colorimetric Detection
- Cat. no.:89156-448
- Supplier No.:AK171-0001
Spécifications
A propos de cet article
Lipid peroxidation is a well-established mechanism of cellular injury in both plants and animals, and is used as an indicator of oxidative stress in cells and tissues. Lipid peroxides, derived from polyunsaturated fatty acids, are unstable and decompose to form a complex series of compounds. These include reactive aldehydes, of which the most abundant is malondialdehyde (MDA). Therefore, measurement of malondialdehyde is widely used as an indicator of lipid peroxidation. Increased levels of lipid peroxidation products have been associated with a variety of chronic diseases in both humans and model systems.
MDA reacts readily with amino groups on proteins and other biomolecules to form a variety of adducts, including cross-linked products
The TBARS method is commonly used to measure MDA in biological samples. However, this reaction is relatively nonspecific; both free and protein-bound MDA can react. The method is designed to assay free MDA or, after a hydrolysis step, total MDA (i.e., free and protein-bound Schiff base conjugates). The assay conditions serve to minimize interference from other lipid peroxidation products, such as 4-hydroxyalkenals.
MDA also forms adducts with DNA bases that are mutagenic and possibly carcinogenic. DNA-protein cross-links are another result of the reaction between DNA and MDA.