To order chemicals, medical devices, or other restricted products please provide ID that includes your business name & shipping address via email [email protected] or fax 484.881.5997 referencing your VWR account number. Acceptable forms of ID are:
- • State issued document with your organization's Federal Tax ID Number
- • State issued document with your organization's Resale Tax ID Number
- • City or County issued Business License
- • State Department of Health Services License
- • Any other ID issued by the State that includes the business name & address
* ATTN: California Customers may require additional documentation as part of the CA Health & Safety Code. Products that fall under this regulation will be placed on a mandatory 21-day hold after documentation is received. VWR will not lift restrictions for residential shipping addresses.
Spécifications
- Antibody type:Primary
- Antigen name:Receptor activator of nuclear factor kappa-B ligand
- Clonality:Monoclonal
- Clone:12A668
- Gene ID:21943
- Host:Mouse
- Isotype:IgG1
- Reactivity:Mouse
- Antigen symbol:RANKL
- Conjugation:Unconjugated
- ImmunoChemistry:Yes
- Size:100 μg
- Western blot:Yes
- Antigen synonyms:RANKLigand|Osteoprotegerin ligand|OPGL|sOdf|ODF|TRANCE|CD254|TNF-related activation-induced cytokine|RANKL|Receptor activator of nuclear factor kappa B ligand|hRANKL2|OPTB2
- Storage buffer:PBS containing 0.05% BSA and 0.05% sodium azide was added as a preservative .
- Storage temperature:Keep as concentrated solution. Store at 4 °C short term. For extended storage aliquot and store at –20 °C or below. Avoid freeze-thaw cycles.
- Concentration:0.5 mg/ml
- Immunogen:Fusion protein, corresponding to amino acids 1-317 of Mouse sRANKL.
- Tested applications:IHC, WB
- Purification:Protein G purified
- Cat. no.:89359-764
- Supplier No.:GTX13582
Spécifications
A propos de cet article
sRANKL is a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis.
We recommend the following starting dilutions:
For WB: Use at a concentration of 0.5-2 µg/ml.
For IHC-P: Use at a concentration of 5 µg/ml.
For FACS: Use at a assay dependent dilution.
Optimal dilutions should be determined experimentally by the end user.
Type: Primary
Antigen: RANKL
Clonality: Monoclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Mouse